COVID and the brain: researchers zero in on how damage occurs

M Marshall - Nature, 2021 - nature.com
brain samples from 26 people who had died with COVID-19. In the five whose brain cells
showed evidence of SARSCoV-2 … can pass through the bloodbrain barrier, and contribute to …

Does SARS-CoV-2 infection cause chronic neurological complications?

ER Hascup, KN Hascup - Geroscience, 2020 - Springer
SARS-CoV-2 can infect cardiomyocytes expressing ACE2 receptors causing elevated
reactive oxygen species resulting in cellular damage… to acute cardiac injury. The subsequent …

[PDF][PDF] Be aware of SARS-CoV-2 spike protein: There is more than meets the eye

TC Theoharides, P Conti - J Biol Regul Homeost Agents, 2021 - mastcellmaster.com
… that the spike protein by itself (without being part of the corona virus) can damage endothelial
cells and disrupt the blood-brain barrier. These findings may be even more relevant to the …

Immune response and bloodbrain barrier dysfunction during viral neuroinvasion

Z Chen, G Li - Innate Immunity, 2021 - journals.sagepub.com
… levels of DHA in the brain, accompanied by neuronal cell loss in the hippocampus and …
This evidence suggests that SARS-CoV-2 may use brain endothelial cells to cross the BBB …

The neurobiology of SARS-CoV-2 infection

J Meinhardt, S Streit, C Dittmayer, RV Manitius… - Nature Reviews …, 2024 - nature.com
… the bloodbrain barrier and blood–cerebrospinal fluid barrier — as systemic factors from the
periphery appear to primarily influence barriers and … cause damage to the CNS, as the brain

Central nervous system complications associated with SARS-CoV-2 infection: integrative concepts of pathophysiology and case reports

S Najjar, A Najjar, DJ Chong, BK Pramanik… - Journal of …, 2020 - Springer
… Pro-inflammatory cytokines can disrupt blood-brain barrier (BBB) and increase its … ), parallel
to the ability of SARS-CoV to induce neuronal injury in mice transgenic for human ACE2 via …

SARS-CoV-2 (COVID-19) as a predictor of neuroinflammation and neurodegeneration: Potential treatment strategies

MV Putilina, DV Grishin - Neuroscience and Behavioral Physiology, 2021 - Springer
… in the bloodbrain barrier (BBB), so endothelial dysfunction is always associated with damage
to … to enter the damaged part of the brain [8]. Migrating immunocompetent cells (along with …

[HTML][HTML] What SARS-CoV-2 does to our brains

T Aschman, R Mothes, FL Heppner, H Radbruch - Immunity, 2022 - cell.com
… If we compare incidences of neurological symptoms among the millions of SARS-CoV-2-…
chronologically in correlation to or as coincidence of SARS-CoV-2 infection. More recent studies …

SARS-CoV-2 invasion of the central nervous: a brief review

R Siddiqui, MR Mungroo, NA Khan - Hospital Practice, 2021 - Taylor & Francis
… cell damage, (ii) viral traversal of the blood-brain barrier … , (iii) viral traversal of the blood-brain
barrier via paracellular route … of SARS-CoV-2 into the brain through the blood-brain barrier

Involvement of the nervous system in SARS-CoV-2 infection

H Li, Q Xue, X Xu - Neurotoxicity research, 2020 - Springer
… neurons damageSARS-CoV-2 binds to ACE2 protein that is abundantly expressed in
endothelial cells, disrupting endothelial cells and the blood-brain barrier and leading to cerebral