Interactions of SARS-CoV-2 with the bloodbrain barrier

MA Erickson, EM Rhea, RC Knopp… - International Journal of …, 2021 - mdpi.com
brain and blood compartments. In this review, we discuss mechanisms by which SARS-CoV-2 …
dysfunction associated with coronavirus disease of 2019 (COVID-19), which is caused by …

Neurological complications associated with the blood-brain barrier damage induced by the inflammatory response during SARS-CoV-2 infection

I Alquisiras-Burgos, I Peralta-Arrieta… - Molecular …, 2021 - Springer
… and brain damage. Then, we analyzed and described the possible mechanisms causative
of brain injury after SARS-CoV-2 infection. We proposed that potential routes of SARS-CoV-2 …

[HTML][HTML] The S1 protein of SARS-CoV-2 crosses the bloodbrain barrier in mice

EM Rhea, AF Logsdon, KM Hansen, LM Williams… - Nature …, 2021 - nature.com
… Severe acute respiratory syndrome coronavirus 2 binds to cells via the S1 subunit of …
bloodbrain barrier in male mice, was taken up by brain regions and entered the parenchymal brain

Anti–SARS-CoV-2 antibodies in the CSF, blood-brain barrier dysfunction, and neurological outcome: studies in 8 stuporous and comatose patients

H Alexopoulos, E Magira, K Bitzogli… - Neurology …, 2020 - AAN Enterprises
… respiratory syndrome coronavirus 2 (SARS-CoV-2) in the serum and CSF using a Food
and Drug Administration-approved and independently validated ELISA. Blood-brain barrier (BBB…

SARS-CoV-2 crosses the bloodbrain barrier accompanied with basement membrane disruption without tight junctions alteration

L Zhang, L Zhou, L Bao, J Liu, H Zhu, Q Lv… - Signal transduction and …, 2021 - nature.com
SARS-CoV-2 invades the brain and infects brain vascular endothelial cells, leading to brain
… Besides, we found the co-localization of SARS-CoV-2-S with blood vessels in the cortex of …

Can SARS-CoV-2 infect the central nervous system via the olfactory bulb or the blood-brain barrier?

SM Burks, H Rosas-Hernandez… - Brain, behavior, and …, 2021 - Elsevier
… Accordingly, SARS-CoV-2 could infect the brain if the virus reaches the brain, potentially
via the OE, vagus nerve, blood brain barrier (BBB), or cerebral spinal fluid (CSF). …

The blood-brain barrier is dysregulated in COVID-19 and serves as a CNS entry route for SARS-CoV-2

S Krasemann, U Haferkamp, S Pfefferle, MS Woo… - Stem cell reports, 2022 - cell.com
… While BCECs were not compromised in their paracellular tightness, we found SARS-CoV-2 …
of virus across the blood-brain barrier (BBB) in vitro. Moreover, entry of SARS-CoV-2 into …

Bloodbrain barrier injury and neuroinflammation induced by SARS-CoV-2 in a lung–brain microphysiological system

P Wang, L Jin, M Zhang, Y Wu, Z Duan, Y Guo… - Nature Biomedical …, 2023 - nature.com
SARS-CoV-2 via the blood route. It should be noted that we considered only one potential
entry route of SARS-CoV-2 into the brain … nervous system, the blood–cerebrospinal fluid barrier…

[HTML][HTML] The SARS-CoV-2 spike protein alters barrier function in 2D static and 3D microfluidic in-vitro models of the human bloodbrain barrier

TP Buzhdygan, BJ DeOre, A Baldwin-Leclair… - Neurobiology of …, 2020 - Elsevier
… from the SARS-CoV-2 viral spike protein on primary human brainbrain tissue, we show
that the angiotensin converting enzyme 2 or ACE2 (a known binding target for the SARS-CoV-2 …

SARS-CoV-2 poorly replicates in cells of the human blood-brain barrier without associated deleterious effects

O Constant, J Barthelemy, K Bollore, E Tuaillon… - Frontiers in …, 2021 - frontiersin.org
… We observed low replication of SARS-CoV-2 that was accompanied by very moderate …
of brain access following SARS-CoV-2 infection does not seem to be directed by brain