Immunosenescence: A systems-level overview of immune cell biology and strategies for improving vaccine responses

SN Crooke, IG Ovsyannikova, GA Poland… - Experimental …, 2019 - Elsevier
… on the applications of systems biology to the study of … biology can be used to inform the
design of new vaccine candidates that are directly engineered to stimulate robust responses in …

Systems biology in vaccine design

A Six, B Bellier, V Thomas‐Vaslin… - Microbial …, 2012 - Wiley Online Library
… and protective vaccine response. The consistency of these predictive signatures across
several trials, for both CD8+ T cell and antibody responses to the yellow fever vaccine, raises the …

A systems biology approach to the effect of aging, immunosenescence and vaccine response

GA Poland, IG Ovsyannikova, RB Kennedy… - Current opinion in …, 2014 - Elsevier
… to vaccine response. We cover how the application of systems biology can advance our
understanding of vaccine … to overcome the lower immunogenicity of vaccines in the elderly. …

Designing spatial and temporal control of vaccine responses

GA Roth, VCTM Picece, BS Ou, W Luo… - Nature Reviews …, 2022 - nature.com
… mechanisms and unknowns of the vaccine immune response. We highlight the … cell activation,
the B cell response and the generation of a potent and durable adaptive immune response

Cell-based systems biology analysis of human AS03-adjuvanted H5N1 avian influenza vaccine responses: a phase I randomized controlled trial

LM Howard, KL Hoek, JB Goll, P Samir, A Galassie… - PLoS …, 2017 - journals.plos.org
… by correlating traditional antibody and cell-mediated immune responses with … biology
approach to study the immune responses in six individual immune cell types following vaccination

Modulating vaccine responses with dendritic cells and Toll‐like receptors

B Pulendran - Immunological reviews, 2004 - Wiley Online Library
… These cytokines may prove to have particular significance to vaccinologists seeking to
augment/modulate vaccine responses by enhancing the number of DCs in vivo. …

A cell-based systems biology assessment of human blood to monitor immune responses after influenza vaccination

KL Hoek, P Samir, LM Howard, X Niu, N Prasad… - PloS one, 2015 - journals.plos.org
cellcell types to the immune response after vaccination, we established a rapid and efficient
method to purify human T and B cells, natural killer (NK) cells, myeloid dendritic cells (mDC)…

Systems biology approaches to new vaccine development

AL Oberg, RB Kennedy, P Li, IG Ovsyannikova… - Current opinion in …, 2011 - Elsevier
… performed by us and others have demonstrated that by understanding crucial genetic
determinants of immune response, we may reveal the basis of vaccine low-response or non-…

Cellular vaccine approaches

DT Le, DM Pardoll, EM Jaffee - The Cancer Journal, 2010 - journals.lww.com
… this review, cellular vaccines are defined as vaccines that use whole cells or cell lysates either
… inhibited a vaccine-induced immune response because docetaxel does affect white blood …

Heterogeneity in vaccine immune response: the role of immunogenetics and the emerging field of vaccinomics

GA Poland, IG Ovsyannikova… - Clinical …, 2007 - Wiley Online Library
… and rational development of new vaccines, and this new golden age … a vaccine response
or an adverse response to a vaccine, the number of doses needed and even whether a vaccine