An evaluation of methods correcting for cell-type heterogeneity in DNA methylation studies

K McGregor, S Bernatsky, I Colmegna, M Hudson… - Genome biology, 2016 - Springer
… , built on cell-separated DNA methylation profiles from Illumina Infinium 450K methylation
data, to … The sites were selected to highlight the methylation differences between cell types. …

Dynamic DNA methylation across diverse human cell lines and tissues

KE Varley, J Gertz, KM Bowling, SL Parker… - Genome …, 2013 - genome.cshlp.org
cell types, and is disrupted in many diseases. We describe large-scale single-base resolution
DNA methylation … This revised model changes our expectations of the type of methylation

Discovering high-resolution patterns of differential DNA methylation that correlate with gene expression changes

ND VanderKraats, JF Hiken, KF Decker… - Nucleic acids …, 2013 - academic.oup.com
… To discover DNA methylation changes that associate with gene expression changes, we
propose a new method that uses the entire differential methylation profile in the vicinity of a …

A DNA methylation map of human cancer at single base-pair resolution

E Vidal, S Sayols, S Moran, A Guillaumet-Adkins… - Oncogene, 2017 - nature.com
cell-type compositions. To analyze DNA methylation variation from different perspectives, we
… reference data sets for cancer samples that included primary tumors and cancer cell lines. …

DNA methylation patterns associate with genetic and gene expression variation in HapMap cell lines

JT Bell, AA Pai, JK Pickrell, DJ Gaffney, R Pique-Regi… - Genome biology, 2011 - Springer
variation in DNA methylation profiles. Furthermore, there was an enrichment of SNPs that
affect both methylation … of the methylation array provides a relatively low resolution snapshot of …

Enhanced cell deconvolution of peripheral blood using DNA methylation for high-resolution immune profiling

LA Salas, Z Zhang, DC Koestler, RA Butler… - Nature …, 2022 - nature.com
… The increased detail in describing leukocyte subtypes using the extended libraries will be
crucial for controlling for aging-related DNA methylation changes; age-associated changes in …

Comparative DNA methylation analysis to decipher common and cell type-specific patterns among multiple cell types

X Yang, X Shao, L Gao, S Zhang - Briefings in functional …, 2016 - academic.oup.com
… can also profile DNA methylation at single-base resolution [40, 41]. … DNA methylation in
many cell types or tissues to study dynamic DNA methylation changes across different cell types, …

A human DNA methylation atlas reveals principles of cell type-specific methylation and identifies thousands of cell type-specific regulatory elements

N Loyfer, J Magenheim, A Peretz, G Cann, J Bredno… - Biorxiv, 2022 - biorxiv.org
… , for identifying pathological changes in DNA methylation, and for the interpretation of …
The resolution of the atlas yields a quantitative understanding of composite tissues, and …

Profiling genome-wide DNA methylation

WS Yong, FM Hsu, PY Chen - Epigenetics & chromatin, 2016 - Springer
… allow the construction of genomic maps of DNA methylation at single-base resolution [30]. In
the … Weak DNA methylation differences can be better measured by estimating the standard …

Human body epigenome maps reveal noncanonical DNA methylation variation

MD Schultz, Y He, JW Whitaker, M Hariharan… - Nature, 2015 - nature.com
DNA methylation across human tissues better, we obtained post-mortem samples of 18 tissue
types … Here we have presented the deepest set of base resolution maps of mCG and mCH …