… best deliver value to drug discovery portfolios and can contribute to the identification and
the development of novel medicines, and to illustrate the challenges and uncertainties that are …

… summarize the importance of plants in drug discovery, current perspectives and challenges.
… drug discovery, the importance of plants in drug discovery, current perspectives, challenges …

… Nevertheless, there are signs that drug discovery in the 21st century will see more intentional
government, academic and industrial collaborations to overcome the above challenges …

… there is a large gap between the initial drug discovery phase, including their validation as
drug models, and their use in a clinical study. Drug candidates must pass through an extensive …

This review article focuses on pre-clinical and clinical studies with some selected Brazilian
medicinal plants in different areas of interest, conducted by research groups in Brazil and …

… The success rate is less than 6% of new drug discovery and development, which is far
away … to accelerate drug discovery to advance the success rate of drug development. Drug …

… and discuss major challenges and opportunities of polypharmacology in drug discovery. In
… therapies, potential drug promiscuity arising from off-target effects, drug repurposing, and …

… This overview summarize the challenges in drug discovery in China in anticancer,
antiallergy, anti-infectious, and pCM for various chronic diseases (such as the allergic diseases …

… and new chemical entity (NCE) discovery. This paper provides a brief perspective on the
evolution and use of key drug design technologies, highlighting opportunities and challenges. …

… review the TB discovery efforts at NITD and share experiences in optimisation of phenotypic
hits, describing challenges encountered and lessons learned. We also offer perspectives to …