The quest for genetic determinants of human longevity: challenges and insights

K Christensen, TE Johnson, JW Vaupel - Nature Reviews Genetics, 2006 - nature.com
challenges face researchers trying to identify genetic variants that are associated with human
longevity, … We begin with a brief overview of the study of longevity in animal models, from …

Untangling the genetics of human longevity—a challenging quest

S Dato, M Soerensen, G Rose - Genes, 2019 - mdpi.com
challenges remain to be addressed in the search for the genetic components of human
longevity. … covering different areas in the field of human longevity, to help the reader take stock of …

The scientific quest for lasting youth: prospects for curing aging

JP de Magalhaes - Rejuvenation research, 2014 - liebertpub.com
human aging. I argue that curing aging is scientifically possible and not even the most
challenging … will lead to a modest increase in human longevity. Another difficulty is that the exact …

From life span to health span: declaring “victory” in the pursuit of human longevity

SJ Olshansky - Cold Spring Harbor Perspectives …, 2022 - perspectivesinmedicine.cshlp.org
… The time has arrived to declare victory in humanity's quest to combat the scourges … humanity
live healthier lives on the heels of a declared success in our effort to combat the challenges

[图书][B] The longevity revolution: The benefits and challenges of living a long life

RN Butler - 2009 - books.google.com
… If we are to successfully meet the challenges of the Longevity Revolution we must have
the … Ageism and a youth quest are prominent in our society. Even older people are seeking …

Exceptional human longevity

RJ Pignolo - Mayo Clinic Proceedings, 2019 - Elsevier
… of more reliable markers associated with longevity, better guidance for appropriate health …
longevity. Overall, the aggregate literature supports that the basis for exceptional longevity

Living in an age of longevity: Enduring insights and perspectives for embarking on a quest for health and well-being in later life

T Seedsman - OBM Geriatrics, 2022 - lidsen.com
… , challenges, imperatives and concerns emanating from the demographic phenomenon of
human longevity … aging, living in an age of longevity, human finitude, resilient aging and self-…

Genetics of extreme human longevity to guide drug discovery for healthy ageing

ZD Zhang, S Milman, JR Lin, S Wierbowski, H Yu… - Nature …, 2020 - nature.com
… conserved pathways that significantly correlate with longevity. In this Perspective, we summarize
recent insights into the genetics of extreme human longevity and propose the use of this …

Extending human longevity: A biological probability

R Arking - The fountain of youth: Cultural, scientific, and ethical …, 2004 - books.google.com
… But that quest has now moved from myth to laboratory report, with the result that we as a
society … I am one of many engaged in this quest, and I think it is time to consider seriously what …

[图书][B] The quest for immortality: Science at the frontiers of aging

BA Carnes, SJ Olshansky - 2002 - books.google.com
… and longevity that we … humanity, for the first time, an opportunity to influence the biological
forces that govern life and death. In this book, we offer a vision of human aging and longevity