… proteases known to activate coronavirus S proteins. We review what is known about coronavirus
proteolytic … and its link with pathogenicity, cell and tissue tropism and host range. We …

… entry solely or mainly to the efficiency of lysosomal proteases in activating coronavirus spike…
proteases from bat cells support coronavirus spike-mediated pseudovirus entry and cell-cell …

… cleaved in virus-infecting cells during virus-cell entry. Here, we … -like cells, but are dispensable
for infection of several other cell … -CoVs dictates cell tropism, and points to spike proteolytic …

… The safety pin is discharged upon interaction with a specific receptor and processing by host
cell proteases and thereby gives way to conformational changes of the instable S 2 subunit. …

… a receptor for cellular entry [… tropism for ciliated cells widely distributed along the upper and
lower respiratory tract [19, 29]. Key factors for CoVs entry into cells are host cellular proteases …

… Severe acute respiratory syndrome coronavirus (SARS-CoV) poses a … by host cell proteases
is essential for viral infectivity. However, the cleavage sites in SARS-S and the protease(s) …

… process, host cells namely coronaviruses, the nature this of the description host protease(s)
omits key essential … the a panel broader of well-characterized tropism of the viru human …

… viral and host cell membranes and viral cell entry. Cleavage of HA is … proteases determining
cell tropism of virus strains (16). There are two major mechanisms responsible for proteolytic …

… and various proteases to coronavirus infection and identifies an unexpected class of … MHV
is useful for studying the contribution of host fusion factors to coronavirus tropism because …

… For this, the S protein combines two biological functions: First, its surface unit, S1, binds to
a specific receptor located at the surface of host cells and thereby determines cellular tropism …