COVID-19 and cellular senescence

CA Schmitt, T Tchkonia, LJ Niedernhofer… - Nature Reviews …, 2023 - nature.com
… The clinical severity of coronavirus disease 2019 (COVID-19… to cellular senescence, an
ageing-related switch in cellular … , can induce senescence and exacerbates the senescence-…

Cellular senescence as a potential mediator of COVID19 severity in the elderly

J Nehme, M Borghesan, S Mackedenski, TG Bird… - Aging cell, 2020 - Wiley Online Library
… Here, we discuss how cellular senescence—a state of … COVID-19 pathogenesis, and a
potential pharmaceutical target to alleviate disease severity. First, we define why older COVID-19

[HTML][HTML] The emerging role of cellular senescence in complications of COVID-19

M Mohiuddin, K Kasahara - Cancer Treatment and Research …, 2021 - Elsevier
cellular senescence in cancer patients during the COVID-19 … the association between cellular
senescence and COVID 19. This … to clear senescent cells during the COVID-19 pandemic. …

Cellular senescence is a potential severity factor for COVID-19: Suitable targets required to eliminate cellular senescence

M Mohiuddin, K Kasahara - Respiratory Medicine, 2021 - resmedjournal.com
COVID-19 pandemic, clinical data on the association between cellular senescence and
COVID-19 … to study the impact of cellular senescence on COVID-19 complications in the future. …

Virus-induced senescence is a driver and therapeutic target in COVID-19

S Lee, Y Yu, J Trimpert, F Benthani, M Mairhofer… - Nature, 2021 - nature.com
… Little is known about systemic ramifications of cellular senescence as an antiviral host
defence. We hypothesize here that cellular senescence and its SASP, which is largely composed …

Lung epithelial and endothelial damage, loss of tissue repair, inhibition of fibrinolysis, and cellular senescence in fatal COVID-19

F D'Agnillo, KA Walters, Y Xiao, ZM Sheng… - Science translational …, 2021 - science.org
… Our study also demonstrated epithelial and endothelial cell senescence in the pathophysiology
of COVID-19, consistent with increased susceptibility and severity of COVID-19 in the …

[HTML][HTML] Role of senescence in the chronic health consequences of COVID-19

EOW Gerdes, G Vanichkachorn, BP Verdoorn… - Translational …, 2022 - Elsevier
… not have fatigue and generalized pain after acute COVID-19. In preliminary studies, we
observed increases in markers of cellular senescence and certain SASP factors in patients with …

Evidence that SARS-CoV-2 induces lung cell senescence: potential impact on COVID-19 lung disease

L Lipskaia, P Maisonnasse, C Fouillade… - … of Respiratory Cell …, 2022 - atsjournals.org
coronavirus disease (COVID-19) (1). Understanding the biological mechanisms linking age
to the pathogenesis of COVID-19 is … We hypothesized that cell senescence, a basic aging …

[HTML][HTML] An account of immune senescence in the clinical pathophysiology of COVID-19 infection in aging

S Jain, E Abrham, MN Khan, R Mathur - Aging and disease, 2021 - ncbi.nlm.nih.gov
… In this review, we address the epidemiology of SARS-CoV-2 and the cellular senescence
COVID-19 infection. The review majorly explores an underline mechanism of how senescent

Cellular senescence: friend or foe to respiratory viral infections?

WJ Kelley, RL Zemans… - European Respiratory …, 2020 - Eur Respiratory Soc
Cellular senescence and respiratory viral infections The coronavirus disease 2019 (COVID-19) …
Given this, how cellular senescence impacts the host response to acute respiratory viral …