Risk-focused differences in molecular processes implicated in SARS-CoV-2 infection: corollaries in DNA methylation and gene expression

C Konwar, R Asiimwe, AM Inkster, SM Merrill… - Epigenetics & …, 2021 - Springer
… In addition, we found differential DNA methylation patterns by COVID-19 status for genes,
such as NLRP2 and ACE2 in an exploratory analysis of an empirical data set reporting on …

Differential methylation as a mediator of COVID-19 susceptibility

S Steyaert, G Trooskens, JR Delanghe… - BioRxiv, 2020 - biorxiv.org
… individuals we hypothesized that differential DNA methylation profiles could be (one of) the
… risk factors for COVID-19. Our results propose that variable methylation can explain (part of) …

DNA methylation profiles in pneumonia patients reflect changes in cell types and pneumonia severity

M Morselli, C Farrell, D Montoya, T Gören, R Sabırlı… - Epigenetics, 2022 - Taylor & Francis
… In this study, we explore the relationship between DNA methylation and clinical features
of Covid-19 infection. Our study population included several groups: those that were PCR …

[HTML][HTML] DNA Methylation Architecture of the ACE2 gene in Nasal Cells

A Cardenas, SL Rifas-Shiman, JE Sordillo, DL DeMeo… - medRxiv, 2020 - ncbi.nlm.nih.gov
… to our understanding COVID-19 severity and disparities … -CoV-2 infectivity and COVID-19
severity via greater abundance of … Therefore, we hypothesize that observed DNA methylation

[HTML][HTML] Characterization of altered gene expression and histone methylation in peripheral blood mononuclear cells regulating inflammation in covid-19 patients

X Yang, AC Rutkovsky, J Zhou, Y Zhong… - The Journal of …, 2022 - journals.aai.org
… One of the major underlying causes of death in COVID-19 … severe form of COVID-19 (6, 7),
treating COVID-19 patients with … mechanisms such as histone/DNA methylation, miRNA, and …

PO. 8.165 Whole-blood dna methylation analysis reveals respiratory environmental traits involved in COVID-19 severity following SARS-CoV-2 infection

G Barturen, E Carnero-Montoro, M Martínez-Bueno… - 2022 - lupus.bmj.com
… the immune processes behind COVID-19 progression, however … DNA methylation in
COVID-19 progression by means of a genome-wide DNA methylation analysis combined with DNA

Elucidating the genetic architecture of DNA methylation to identify promising molecular mechanisms of disease

J Ma, R Joehanes, C Liu, A Keshawarz, SJ Hwang… - Scientific reports, 2022 - nature.com
… We analyzed whole genome sequencing data to identify DNA methylation quantitative trait …
with COVID-19 severity. To assist in future analyses of the role of DNA methylation in disease …

A role of glycation and methylation for SARS-CoV-2 infection in diabetes?

G Sartore, E Ragazzi, L Faccin, A Lapolla - Medical Hypotheses, 2020 - Elsevier
… , and DNA methylation of … of COVID-19 in people with diabetes could be related, at least
in part, to the two mechanisms already suggested for cancer patients, specifically methylation

DNA methylation and gene expression pattern of ACE2 and TMPRSS2 genes in saliva samples of patients with SARS-CoV-2 infection

P Misra, B Mukherjee, R Negi, V Marwah, AK Ghosh… - medRxiv, 2020 - medrxiv.org
… of patients infected with COVID-19. The study aimed to quantify promoter methylation of ACE2
… In conclusion, we found that ACE2 and TMPRSS2 methylation plays a role in COVID-19. …

[HTML][HTML] Cell-free DNA maps COVID-19 tissue injury and risk of death and can cause tissue injury

TE Andargie, N Tsuji, F Seifuddin, MK Jang, PST Yuen… - JCI insight, 2021 - ncbi.nlm.nih.gov
… tissue-specific DNA methylation signatures to investigate the sources of cfDNA in patients
with COVID-19, patients with influenza and/or RSV, and healthy controls (Figure 2). COVID-19