Blood DNA methylation and COVID-19 outcomes

J Balnis, A Madrid, KJ Hogan, LA Drake, HC Chieng… - Clinical …, 2021 - Springer
… In this prospective cohort study, we tested the hypothesis that COVID-19 patients
demonstrate patterns of DNA methylation in blood that are different from pre-pandemic healthy …

An epigenome‐wide DNA methylation study of patients with COVID19

S Zhou, J Zhang, J Xu, F Zhang, P Li… - Annals of human …, 2021 - Wiley Online Library
… to shed light on the DNA methylation changes in healthy subjects and patients with different
severities of COVID-19 to explore novel targets and effective methods for treating COVID-19. …

Genome-wide DNA methylation profiling of peripheral blood reveals an epigenetic signature associated with severe COVID-19

MJ Corley, APS Pang, K Dody, PA Mudd… - Journal of leukocyte …, 2021 - academic.oup.com
… Although most patients with COVID-19 have mild illness and … DNA methylation (DNAm)
profiles of peripheral blood mononuclear cells from 9 terminally-ill, critical COVID-19 patients with …

Whole blood DNA methylation analysis reveals respiratory environmental traits involved in COVID-19 severity following SARS-CoV-2 infection

G Barturen, E Carnero-Montoro… - Nature …, 2022 - nature.com
… and NK-cells from severe COVID-19 patients 34 , which in light of our DNA methylation
results might be impaired, as could be explained by the DNA hypermethylation of genes of the …

Genetic alteration, RNA expression, and DNA methylation profiling of coronavirus disease 2019 (COVID-19) receptor ACE2 in malignancies: a pan-cancer analysis

P Chai, J Yu, S Ge, R Jia, X Fan - Journal of hematology & oncology, 2020 - Springer
… Notably, many of affected patients of COVID-19 were people with malignancies. … DNA
methylation level of KICH across different tumor stages, and we found that the DNA methylation

DNA methylation predicts the outcome of COVID-19 patients with acute respiratory distress syndrome

M Bradic, S Taleb, B Thomas, O Chidiac… - Journal of Translational …, 2022 - Springer
… 100 COVID-19 patients with ARDS under mechanical ventilation and 33 non-COVID-19
We first assessed methylation changes between COVID-19 patients and controls at the study’s …

A machine learning approach utilizing DNA methylation as an accurate classifier of COVID-19 disease severity

S Bowler, G Papoutsoglou, A Karanikas… - Scientific Reports, 2022 - nature.com
… set, we removed non-ICU COVID-19 patients from the validation dataset to explore if the
model was more precise at classifying these severe COVID-19 patients. Under these conditions, …

Epigenomics in COVID-19; the link between DNA methylation, histone modifications and SARS-CoV-2 infection

M Shirvaliloo - Epigenomics, 2021 - Taylor & Francis
… -associated thrombotic events, Cit-H3 has reported to be positively correlated with the count
of platelets [2], whose activity is implicated to be strengthened in COVID-19 patients due to a …

[HTML][HTML] Identification of whole-blood DNA methylation signatures and rules associated with COVID-19 severity

F Yuan, JX Ren, HP Liao, W Guo, L Chen… - Frontiers in Bioscience …, 2023 - imrpress.com
… associated with the progression of COVID-19. Methods: In … -blood DNA methylation data
from COVID-19 patients with … role of DNA methylation in the development of COVID-19. The …

[HTML][HTML] Blood DNA methylation in post-acute sequelae of COVID-19 (PASC): a prospective cohort study

J Balnis, A Madrid, LA Drake, R Vancavage, A Tiwari… - eBioMedicine, 2024 - thelancet.com
… dinucleotides in each patient (>25 million unique CpGs), provides a substantially higher
resolution (∼30-fold) to capture persistent COVID-19-induced DNA methylation changes in …