COVID19 critical illness pathophysiology driven by diffuse pulmonary thrombi and pulmonary endothelial dysfunction responsive to thrombolysis

HD Poor, CE Ventetuolo, T Tolbert… - Clinical and …, 2020 - Wiley Online Library
… ill COVID-19 patients … COVID-19 infection and significantly elevated d-dimers. An autopsy
of a patient at our institution with severe COVID-19 disease revealed numerous pulmonary

Pulmonary vascular endothelialitis, thrombosis, and angiogenesis in Covid-19

M Ackermann, SE Verleden, M Kuehnel… - … England Journal of …, 2020 - Mass Medical Soc
coronavirus disease 2019 (Covid-19) pandemic. Despite widespread interest in the
pathophysiology of … and molecular changes in the peripheral lung of patients who die from …

A tricompartmental model of lung oxygenation disruption to explain pulmonary and systemic pathology in severe COVID-19

D McGonagle, C Bridgewood… - The Lancet Respiratory …, 2021 - thelancet.com
… We also consider how immunothrombosis of the pulmonary venous drainage territory in
COVID-19 might contribute to impaired oxygenation and also predispose to clot propagation, …

The possible implication of endothelin in the pathology of COVID-19-induced pulmonary hypertension

OA Nabeh, LM Matter, MA Khattab… - Pulmonary pharmacology …, 2021 - Elsevier
… persistent post COVID-19 pathologies that affect patients’ life [2,3]. Pulmonary hypertension
(… consequence of SARS-COV-2 infection in some COVID-19 survivors [4,5]. The vasopressor, …

Pathophysiology of pulmonary fibrosis in the context of COVID-19 and implications for treatment: A narrative review

S Tran, A Ksajikian, J Overbey, P Li, Y Li - Cells, 2022 - mdpi.com
… of the COVID-19 pandemic. With the massive scale of the COVID-19 pandemic, we expect
there should more instances of PF due to COVID-19 infection. Patients who survive severe …

Persistent pulmonary pathology after COVID-19 is associated with high viral load, weak antibody response, and high levels of matrix metalloproteinase-9

TV Lerum, NN Maltzahn, P Aukrust, M Trøseid… - Scientific Reports, 2021 - nature.com
… show that treatment with remdesivir and HCQ for COVID-19 had no significant effect on
pulmonary function test results 3 months following discharge for COVID-19, compared to SoC 5,6 …

[HTML][HTML] Pathology of lung‐specific thrombosis and inflammation in COVID19

RR Khismatullin, AA Ponomareva… - Journal of Thrombosis …, 2021 - Elsevier
… Representative scanning electron microscopy images of a pulmonary blood clot from a
patient who died of COVID19. (A) Compacted polyhedrocytes and a small amount of free …

[HTML][HTML] A systematic review of pathological findings in COVID-19: a pathophysiological timeline and possible mechanisms of disease progression

SB Polak, IC Van Gool, D Cohen, JH von der Thüsen… - Modern Pathology, 2020 - Elsevier
… Shown below the timeline is the approximate occurrence of COVID-19 clinical phases,
color-coded based on the three patterns of histological pulmonary changes, and the transition …

Analysis of cardiopulmonary findings in COVID-19 fatalities: high incidence of pulmonary artery thrombi and acute suppurative bronchopneumonia

C Grosse, A Grosse, HJF Salzer, MW Dünser… - … pathology, 2020 - Elsevier
pathology of COVID-19 based on (non-minimal invasive) autopsies performed on 14 COVID-19
… We classified 5 types of pulmonary thrombi: 1. capillary microthrombi (11/14, 78.6%); 2. …

COVID-19 pneumonia: pathophysiology and management

L Gattinoni, S Gattarello, I Steinberg… - European …, 2021 - Eur Respiratory Soc
… understanding of COVID-19 pathophysiology and provide … , that the progression of
COVID-19 disease may resolve at any … of pulmonary blood flow and pulmonary artery pressure. …