… -2 spike or the virus’ human receptor affect … a COVID-19 therapy, and have revealed the
scope of mutational tolerance within the spike that may have bearing on genetic drift as the virus …

… As the viral RNA genome is amplified in the cell, the effects of the mutagen are concentrated
in the viral … Favipiravir is now being evaluated in multiple human trials to treat COVID-19. …

… viral genome have been recognized as important factors affecting the rate of mutations.
Coronavirus disease 2019 (Covid-19) is a novel viral … to cope with Covid-19 is a difficult and time-…

… virus that causes COVID-19. Clinical trials of molnupiravir as a therapy for patients with
mild-to-moderate COVID-19 … Molnupiravir is lethally mutagenic against viral RNA, but its effect on …

… , we infected Vero cells with a viral strain isolated from a COVID-19 patient. Vero-E6 cells
provide an established cellular system for viral propagation and studies, as apart from their …

… [52,152], combination therapies should be the choice for a most efficient treatment and, in
the case of COVID-19, further studies will be necessary to test the efficacy of molnupiravir …

… viable virus with growth and viral RNA synthesis kinetics similar to that of the parental virus.
… ExoIII mutants were competent in N7-MTase activity (19). Variation in protein synthesis of the …

… COVID-19 therapy. However, the biochemical mechanisms involved in molnupiravir-induced
mutagenesis … A number of successful viral extinctions in cell culture using other mutagenic …

… [52,152], combination therapies should be the choice for a most efficient treatment and, in
the case of COVID-19, further studies will be necessary to test the efficacy of molnupiravir …

… Coronavirus disease 19 (COVID-19) continues to challenge most scientists in the search of
… Herein we discuss the different strategies used in the development of COVID-19 vaccines, …