Immunosenescence: deficits in adaptive immunity in the elderly

FT Hakim, RE Gress - Tissue antigens, 2007 - Wiley Online Library
… The decline in immune competence that occurs with aging has serious clinical … Bacterial
infections in the lungs, skin and urinary tract become more common (1). Viral infections increase …

Viral phenotype and immune response in primary human immunodeficiency virus type 1 infection

MTL Roos, JMA Lange, REY de Goede… - Journal of Infectious …, 1992 - academic.oup.com
… A similar dip in T lymphocyte numbers occurred during acute influenza virus infection (… In
the present study rapid CD4+ T cell decline, however, was only observed in the three persons …

[图书][B] Virus dynamics: mathematical principles of immunology and virology: mathematical principles of immunology and virology

M Nowak, RM May - 2000 - books.google.com
infection in patients. Understanding the population dynamics of the engagement between a
viral infection and the immune … HIV infected patient the abundance of CD4 cells can decline

Control of influenza virus infection by immunity to conserved viral features

SL Epstein - Expert review of anti-infective therapy, 2003 - Taylor & Francis
… In the face of a rapidly spreading outbreak, a race to isolate the virus and prepare a
vaccine would probably not succeed in time to avoid great losses. Thus, additional anti-infection

Control of Viremia in Simian Immunodeficiency Virus Infection by CD8+ Lymphocytes

JE Schmitz, MJ Kuroda, S Santra, VG Sasseville… - Science, 1999 - science.org
… As in HIV-1 infection of humans, primary infectionvirus replication followed by an abrupt
decline in viremia presumably due to the emergence of immune responses that suppress virus

Cytotoxic T-cell immunity to influenza

AJ McMichael, FM Gotch, GR Noble… - New England Journal …, 1983 - Mass Medical Soc
… to immunity against influenza virus infection, we inoculated 63 volunteers intranasally with
live unattenuated influenza A/Munich/1/79 virus… steady decline in cytotoxic T-cell immunity that …

Early kinetics of innate and adaptive immune responses during hepatitis B virus infection

P Fisicaro, C Valdatta, C Boni, M Massari, C Mori… - Gut, 2009 - gut.bmj.com
infection and decline later, concurrently with the decline of viraemia.4 Therefore, additional
studies investigating the interplay between innate and adaptive responses in patients who …

Age-related changes in immunity: implications for vaccination in the elderly

RD Kovaiou, D Herndler-Brandstetter… - Expert reviews in …, 2007 - cambridge.org
… is accumulating that repeated viral infections or the establishment of chronic infections drive
the CD8… might overcome the age-related functional decline of innate immune responses by …

Mitochondrial dysfunction and the aging immune system

PJ McGuire - Biology, 2019 - mdpi.com
… the hypothesis that the decline in immunity and associated … of viral infections, especially
respiratory viral infections, … 65 exhibit a vulnerability to influenza A virus (IAV), and account …

Impact of prior flavivirus immunity on Zika virus infection in rhesus macaques

MK McCracken, GD Gromowski, HL Friberg… - PLoS …, 2017 - journals.plos.org
… within two weeks, and began to decline by day 28. Although IgM titers in the DENV-immune
and YFV-immune animals appeared to decline moderately faster than in the naïve animals, …