Epigenetic aging: Biological age prediction and informing a mechanistic theory of aging

A Li, Z Koch, T Ideker - Journal of internal medicine, 2022 - Wiley Online Library
… Here, we outline emerging areas of epigenetic aging research that prioritize biological …
progress in epigenetic clocks, which are beginning to predict not only chronological age but aging

[HTML][HTML] Epigenetic-aging-signature to determine age in different tissues

CM Koch, W Wagner - Aging (Albany NY), 2011 - ncbi.nlm.nih.gov
… This process is associated with epigenetic modifications such as methylation changes at …
an Epigenetic-Aging-Signature which is applicable for many tissues to predict donor age. DNA-…

Epigenetic age prediction

DJ Simpson, T Chandra - Aging cell, 2021 - Wiley Online Library
Epigenetic clocks have proven themselves to be accurate at predicting chronological age
(chAge), which is commonly referred to as DNAm age or epigenetic age (eAge). When …

Epigenetic predictor of age

S Bocklandt, W Lin, ME Sehl, FJ Sánchez… - PloS one, 2011 - journals.plos.org
… The identification of specific epigenetic patterns highly correlated with age has the potential
to influence our understanding of ageing in health and disease. Specifically, it could lead to …

Improved precision of epigenetic clock estimates across tissues and its implication for biological ageing

Q Zhang, CL Vallerga, RM Walker, T Lin, AK Henders… - Genome medicine, 2019 - Springer
… On the other hand, Horvath’s age predictor outperformed our predictor in samples from
the brain. Their performance in other tissues (breast, liver, adipose, and muscle) was similar, …

Refining epigenetic prediction of chronological and biological age

E Bernabeu, DL McCartney, DA Gadd, RF Hillary… - Genome Medicine, 2023 - Springer
… For this purpose, we use epigenetic surrogates (EpiScores) for 109 plasma proteins and the
… the current best epigenetic predictors of survival. We test this bAge predictor in four external …

New targeted approaches for epigenetic age predictions

Y Han, J Franzen, T Stiehl, M Gobs, CC Kuo, M Nikolić… - BMC biology, 2020 - Springer
… Moreover, the accuracy of our 65 CpG model even outperformed the accuracy of age-predictions
using the epigenetic aging signatures with 353 CpGs [19] or 71 CpGs [17], often …

A new robust epigenetic model for forensic age prediction

A Montesanto, P D'Aquila, V Lagani… - Journal of forensic …, 2020 - Wiley Online Library
… The aging process significantly affects most of the … an epigenetic model for age prediction
was validated in a sample of the Italian population. However, its applicability to advanced ages

DNA methylation-based age clocks: From age prediction to age reversion

R Noroozi, S Ghafouri-Fard, A Pisarek… - Ageing Research …, 2021 - Elsevier
… the aging process in the DNAm landscape to show how epigenetic age clocks evolved from
a chronological age … including epigenetic age estimator (epigenetic age clock), epigenetic

Association of facial ageing with DNA methylation and epigenetic age predictions

RE Marioni, DW Belsky, IJ Deary, W Wagner - Clinical Epigenetics, 2018 - Springer
… the hypothesis that an epigenetic predictor for biological age might be trained on face-age
as a surrogate for biological age rather than on chronological age. Our data demonstrate that …