Recalibrating the epigenetic clock: implications for assessing biological age in the human cortex

GL Shireby, JP Davies, PT Francis, J Burrage… - Brain, 2020 - academic.oup.com
… Existing DNA methylation clocks have been … novel epigenetic clock that performs optimally
in human cortex tissue and has the potential to identify phenotypes associated with biological

[HTML][HTML] Biological age predictors

J Jylhävä, NL Pedersen, S Hägg - EBioMedicine, 2017 - thelancet.com
epigenetic clock is currently the best biological age predictor, as it correlates well with age
Thus far, the most promising, new biological age predictor is the epigenetic clock; however its …

Epigenetic aging: Biological age prediction and informing a mechanistic theory of aging

A Li, Z Koch, T Ideker - Journal of internal medicine, 2022 - Wiley Online Library
… First, we survey recent progress in epigenetic clocks, which are beginning to predict not …
to train epigenetic clocks more directly against biological aging outcomes or to integrate clocks

Epigenetic age prediction

DJ Simpson, T Chandra - Aging cell, 2021 - Wiley Online Library
… In this review, we will discuss the range of epigenetic clocks available, their strengths and
… increases, so too does our understanding of biological age. Depending on how these …

[HTML][HTML] A targeted epigenetic clock for the prediction of biological age

N Gensous, C Sala, C Pirazzini, F Ravaioli, M Milazzo… - Cells, 2022 - mdpi.com
… ) biological age, respectively. These results support the potential of our targeted epigenetic
clock as a new marker of biological age … assessment of biological age in healthcare practice. …

Epigenetic clocks”: Theory and applications in human biology

CP Ryan - American Journal of Human Biology, 2021 - Wiley Online Library
epigenetic clocks, especially as they relate to key theoretical and applied issues in human
biology… of the ways that epigenetic clocks can inform questions in human biology, and vice …

[HTML][HTML] Improved precision of epigenetic clock estimates across tissues and its implication for biological ageing

Q Zhang, CL Vallerga, RM Walker, T Lin, AK Henders… - Genome medicine, 2019 - Springer
… This study indicates that the epigenetic clock can be improved by … attenuates with increased
prediction of chronological age. … biological age-associated CpGs in an improved epigenetic

An epigenetic clock model for assessing the human biological age of healthy aging

XL Ni, HP Yuan, J Jiao, ZP Wang, HB Su… - Zhonghua yi xue za …, 2022 - europepmc.org
age [(76.99±6.78) and (83.97±9.36) mmHg, respectively, ] (all P values<0.05). Conclusion:
The … epigenetic clock model can be used to evaluate and calibrate human biological age. …

The epigenetic clock and aging

K Raj - Epigenetics of aging and longevity, 2018 - Elsevier
… these two examples demonstrate that the epigenetic clock is not impervious to biology of
the body. Instead it is a more accurate indicator of biological age than chronological age. …

DNA methylation-based biomarkers and the epigenetic clock theory of ageing

S Horvath, K Raj - Nature reviews genetics, 2018 - nature.com
… A recent review of six types of potential biological age estimators — epigenetic clocks, … that
the epigenetic clock is the most promising molecular estimator of biological age 15 . Similarly, …