Genome-scale analysis of aberrant DNA methylation in colorectal cancer

T Hinoue, DJ Weisenberger, CPE Lange… - Genome …, 2012 - genome.cshlp.org
… CRC, together with genomic changes, provide a detailed molecular landscape of colorectal
tumors. Our findings here have clinical implications on colorectal cancer diagnosis and may …

Genome-scale analysis of DNA methylation in colorectal cancer using Infinium HumanMethylation450 BeadChips

VA Naumov, EV Generozov, NB Zaharjevskaya… - Epigenetics, 2013 - Taylor & Francis
… used to examine genome-wide DNA methylation profiles in 22 sample pairs from colorectal
cancer (CRC) and adjacent tissues and 19 colon tissue samples from cancer-free donors. …

Genome-scale discovery of DNA-methylation biomarkers for blood-based detection of colorectal cancer

CPE Lange, M Campan, T Hinoue, RF Schmitz… - PloS one, 2012 - journals.plos.org
… samples and other cancer types. We then used pre-therapeutic plasma and serum samples
from 107 colorectal cancer patients and 98 controls without colorectal cancer, confirmed by …

Elucidating the reprograming of colorectal cancer metabolism using genome-scale metabolic modeling

C Zhang, M Aldrees, M Arif, X Li, A Mardinoglu… - Frontiers in …, 2019 - frontiersin.org
… In this report, we have attempted to build genome scale metabolic model for colorectal
cancer and identified key metabolic pathways altered in a local patient cohort. Further, we found …

Genome-scale CRISPR-Cas9 screen of Wnt/β-catenin signaling identifies therapeutic targets for colorectal cancer

C Wan, S Mahara, C Sun, A Doan, HK Chua, D Xu… - Science …, 2021 - science.org
… Over the past decade, a number of functional genomic screens targeting the Wnt/β-catenin
pathway have been performed using focused gene libraries or at whole-genome scale (8, 9). …

[HTML][HTML] Integration of genome scale data for identifying new players in colorectal cancer

V Sokolova, E Crippa, M Gariboldi - World journal of …, 2016 - ncbi.nlm.nih.gov
Colorectal cancers (CRCs) display a wide variety of genomic aberrations that … genomic
analysis have helped to identify a plethora of alterations that can potentially serve as new cancer

Identifying essential genes in genome-scale metabolic models of consensus molecular subtypes of colorectal cancer

CT Cheng, JM Lai, PMH Chang, YR Hong, CYF Huang… - Plos one, 2023 - journals.plos.org
… MDM problem to identify essential targets in genome-scale metabolic models for five
consensus molecular subtypes (CMSs) of colorectal cancer. We used various media to identify …

[HTML][HTML] Integrative genome-scale DNA methylation analysis of a large and unselected cohort reveals 5 distinct subtypes of colorectal adenocarcinomas

L Fennell, T Dumenil, L Wockner, G Hartel… - Cellular and molecular …, 2019 - Elsevier
… In this study, we define the extent and spectrum of DNA methylation changes occurring in
colorectal cancers and relate this to key clinical and molecular events characteristic of defined …

Genome-scale metabolic modeling with protein expressions of normal and cancerous colorectal tissues for oncogene inference

FS Wang, WH Wu, WS Hsiu, YJ Liu, KW Chuang - Metabolites, 2019 - mdpi.com
… and cancer cells to reconstruct two tissue-specific genome-scale … -coding numbers in the
gene association expression to avoid … Colorectal cancer (CRC) was the topic of this case study, …

Reconstruction of the genome-scale co-expression network for the Hippo signaling pathway in colorectal cancer

F Dehghanian, Z Hojati, N Hosseinkhan… - Computers in biology …, 2018 - Elsevier
… In the present study, we conducted a genome-scale co-expression analysis to reconstruct
the HSP in colorectal cancer (CRC). Five key modules were detected through network …