SARS-CoV-2 productively infects human brain microvascular endothelial cells

RC Yang, K Huang, HP Zhang, L Li, YF Zhang… - Journal of …, 2022 - Springer
… of the vascular endothelium in brain. Moreover, we demonstrated that SARS-CoV-2 infection
could … Our findings demonstrated that SARS-CoV-2 infection can cause BBB dysfunction, …

[PDF][PDF] SARS-CoV-2 infects the brain choroid plexus and disrupts the blood-CSF barrier in human brain organoids

L Pellegrini, A Albecka, DL Mallery, MJ Kellner, D Paul… - Cell stem cell, 2020 - cell.com
… that SARSCoV-2 does not readily infect neuronal cells but rather infects ChP epithelial
cells of the brain. This finding is consistent with the high levels of expression of SARS-CoV-2 …

Long-term effects of SARS-CoV-2 infection on human brain and memory

Q Ding, HJ Zhao - Cell Death Discovery, 2023 - nature.com
… , including pathological changes in brains. This review mainly … of SARS-CoV-2 invading
human brain and the molecular basis of SARS-CoV-2 infection interfering with human brain and …

SARSCoV‐2 targets neurons of 3D human brain organoids

A Ramani, L Müller, PN Ostermann, E Gabriel… - The EMBO …, 2020 - embopress.org
SARS-CoV-2 readily targets neurons of 3D human brain organoids. Neurons invaded with
SARS-CoV-… show that although SARS-CoV-2 can readily target brain organoids, SARS-CoV-2 …

SARS-CoV-2 infection and persistence throughout the human body and brain

D Chertow, S Stein, S Ramelli, A Grazioli, JY Chung… - 2021 - researchsquare.com
… -2 cellular 260 tropism, quantification, and persistence across the body and brain, in a diverse
… We show SARS-CoV-2 disseminates across the human body and brain early in infection …

SARS-CoV-2 infectivity and neurological targets in the brain

WJ Lukiw, A Pogue, JM Hill - Cellular and molecular neurobiology, 2022 - Springer
… of the mechanism and pathways of SARS-CoV-2 infection and … SARS-CoV-2 attack in this
communication we analyzed ACE2 expression in 85 human tissues including 21 different brain

[PDF][PDF] Neurotropic effects of SARS-CoV-2 modeled by the human brain organoids

A Ramani, AI Pranty, J Gopalakrishnan - Stem cell reports, 2021 - cell.com
… of SARS-CoV-2 revealed by human brain organoid research. We also highlight the obstacles
incurred using human brain … and identify potential therapeutic agents against SARS-CoV-2. …

SARS-CoV-2 infects human neural progenitor cells and brain organoids

BZ Zhang, H Chu, S Han, H Shuai, J Deng, Y Hu… - Cell research, 2020 - nature.com
… whether SARS-CoV-2 could infect 3D human brain organoids. We generated iPSC-derived
human brain organoids using previously described protocols. The 35-day-old brain

Neuroinvasion of SARS-CoV-2 in human and mouse brain

E Song, C Zhang, B Israelow, A Lu-Culligan… - Journal of Experimental …, 2021 - rupress.org
… mice, and infections of human brain organoids: that SARS-CoV-2 … , and the disruption of brain
vasculature can make vulnerable … of human brain organoids, beyond modeling fetal brains, …

Neurological complications and infection mechanism of SARS-COV-2

D Wan, T Du, W Hong, L Chen, H Que, S Lu… - Signal Transduction and …, 2021 - nature.com
… -2 and discuss the potential mechanisms through which SARS-CoV-2 invades the brain
based on the current evidence. Finally, we summarize the experimental models were used to …