[HTML][HTML] SARS-CoV-2 infection and persistence in the human body and brain at autopsy

SR Stein, SC Ramelli, A Grazioli, JY Chung, M Singh… - Nature, 2022 - nature.com
SARS-CoV-2 across the human body, including the brain, from acute infection to more than
seven months following symptom onset. We show that SARS-CoV-… , including the brain, early …

[PDF][PDF] SARS-CoV-2 receptors and entry genes are expressed in the human olfactory neuroepithelium and brain

L Fodoulian, J Tuberosa, D Rossier, M Boillat, C Kan… - Iscience, 2020 - cell.com
brain cell types, both in mice and humans. Sustentacular cells thus represent a potential entry
door for SARS-CoV… in a neuronal sensory system that is in direct connection with the brain. …

[HTML][HTML] SARS-CoV-2 promotes microglial synapse elimination in human brain organoids

n Samudyata, AO Oliveira, S Malwade… - Molecular …, 2022 - nature.com
… To a large extent, SARS-CoV-2 exposed microglia adopt a transcriptomic profile … risk
after a SARS-CoV-2 infection. Our results reveal that brain organoids infected with SARS-CoV-2 …

[HTML][HTML] Neuropathology and virus in brain of SARS-CoV-2 infected non-human primates

I Rutkai, MG Mayer, LM Hellmers, B Ning… - Nature …, 2022 - nature.com
… -2 infected NHPs and provides key insights into SARS-CoV-2-associated … brain of human
subjects who died with SARS-CoV-2 infection. Additional molecular analyses on brain from our …

Neuroinvasive potential of SARS-CoV-2 revealed in a human brain organoid model

E Song, C Zhang, B Israelow, A Lu-Culligan, A Sprado… - 2020 - pesquisa.bvsalud.org
… First, using human brain organoids, we observed clear evidence of infection with
accompanying metabolic changes in the infected and neighboring neurons. However, no …

[HTML][HTML] Interactions of SARS-CoV-2 with the blood–brain barrier

MA Erickson, EM Rhea, RC Knopp… - International Journal of …, 2021 - mdpi.com
SARS-CoV-2 into the brain, as well as the neuroinflammatory response to SARS-CoV-2
infections. … In summary, there is evidence of brain SARS-CoV-2 entry and infection, which could …

[HTML][HTML] SARS-CoV-2 infects human brain organoids causing cell death and loss of synapses that can be rescued by treatment with Sofosbuvir

P Mesci, JS de Souza, L Martin-Sancho, A Macia… - PLoS …, 2022 - journals.plos.org
… To experimentally determine whether SARS-CoV-2 could replicate in and affect human
brain cells, we infected iPSC-derived human brain organoids. Here, we show that SARS-CoV-2 …

[HTML][HTML] The spatial and cell-type distribution of SARS-CoV-2 receptor ACE2 in the human and mouse brains

R Chen, K Wang, J Yu, D Howard, L French… - Frontiers in …, 2021 - frontiersin.org
… support the hypothesis that SARS-CoV-2 might enter the human brain through the olfactory
nerves. Recently, Meinhardt et al. found the olfactory transmucosal SARS-CoV-2 invasion as …

[HTML][HTML] Infectivity of human coronavirus in the brain

Q Cheng, Y Yang, J Gao - EBioMedicine, 2020 - thelancet.com
… the extent to which SARS-CoV-2 is present in the brain, and if so… has been recognised in
animal and human studies. Given that … Detection of SARS coronavirus RNA in the cerebrospinal …

[HTML][HTML] SARS-CoV-2: is there neuroinvasion?

C McQuaid, M Brady, R Deane - Fluids and Barriers of the CNS, 2021 - Springer
… The main issue is that there is no sound evidence for large flux of SARS-CoV-2 into brain,
at present, to support a brain invasion compared to the lungs and respiratory pathways. …