The expression of SARS-CoV-2 receptor ACE2 and CD147, and protease TMPRSS2 in human and mouse brain cells and mouse brain tissues

J Qiao, W Li, J Bao, Q Peng, D Wen, J Wang… - Biochemical and …, 2020 - Elsevier
… expression in brain cell lines and mouse lung tissues. It is suggested that SARS-CoV-2 might
… the possibility of SARS-CoV-2 infection to human brain nervous system and pathogenicity. …

Blood–brain barrier injury and neuroinflammation induced by SARS-CoV-2 in a lung–brain microphysiological system

P Wang, L Jin, M Zhang, Y Wu, Z Duan, Y Guo… - Nature Biomedical …, 2023 - nature.com
… probe the effects of SARS-CoV-2 infection on the human brain using a lung–brain MPS. Our
… In summary, we studied the effects of SARS-CoV-2 infection on the human brain in an organ…

The neuroinvasiveness, neurotropism, and neurovirulence of SARS-CoV-2

L Bauer, BM Laksono, FMS de Vrij, SA Kushner… - Trends in …, 2022 - cell.com
… contribute to the neuroinvasiveness of SARS-CoV-2. Other possibilities for neuroinvasion
of SARS-CoV-2 are through hematogenous spread via either the blood–brain barrier (BBB) or …

[HTML][HTML] The SARS-CoV-2 spike protein alters barrier function in 2D static and 3D microfluidic in-vitro models of the human blood–brain barrier

TP Buzhdygan, BJ DeOre, A Baldwin-Leclair… - Neurobiology of …, 2020 - Elsevier
… from the SARS-CoV-2 viral spike protein on primary human brainbrain tissue, we show
that the angiotensin converting enzyme 2 or ACE2 (a known binding target for the SARS-CoV-2 …

[HTML][HTML] SARS-CoV-2 deregulates the vascular and immune functions of brain pericytes via Spike protein

R Khaddaj-Mallat, N Aldib, M Bernard… - Neurobiology of …, 2021 - Elsevier
… Although brain pericytes were recently shown to abundantly … to SARS-CoV-2 S protein is
still to be elucidated. Using cell-based assays, we found that ACE2 expression in human brain

[HTML][HTML] Mapping of SARS-CoV-2 brain invasion and histopathology in COVID-19 disease

GE Serrano, JE Walker, R Arce, MJ Glass, D Vargas… - MedRxiv, 2021 - ncbi.nlm.nih.gov
… Two human coronaviruses, strains 229E and OC43, were … , of 90 human brains obtained
from multiple brain banks … that have occurred in humans infected with SCV2 28 – 35 , it is …

Neurological complications associated with the blood-brain barrier damage induced by the inflammatory response during SARS-CoV-2 infection

I Alquisiras-Burgos, I Peralta-Arrieta… - Molecular …, 2021 - Springer
… and brain damage. Then, we analyzed and described the possible mechanisms causative
of brain injury after SARS-CoV-2 infection. We proposed that potential routes of SARS-CoV-2 …

SARS-CoV-2 is associated with changes in brain structure in UK Biobank

G Douaud, S Lee, F Alfaro-Almagro, C Arthofer… - Nature, 2022 - nature.com
… 401 cases who tested positive for infection with SARS-CoV-2 between their two scans—with …
brain size in the SARS-CoV-2 cases. The participants who were infected with SARS-CoV-2 …

[PDF][PDF] Human pluripotent stem cell-derived neural cells and brain organoids reveal SARS-CoV-2 neurotropism predominates in choroid plexus epithelium

F Jacob, SR Pather, WK Huang, F Zhang, SZH Wong… - Cell stem cell, 2020 - cell.com
… To investigate the susceptibility of human brain cells to SARSCoV-2 infection, we tested
various hiPSC-derived neural cells in monolayer cultures and region-specific brain organoids …

Detection of SARS-CoV-2 viral proteins and genomic sequences in human brainstem nuclei

A Emmi, S Rizzo, L Barzon, M Sandre… - npj Parkinson's …, 2023 - nature.com
… Despite reports of SARS-CoV-2 detection in the brain and cerebrospinal fluid of COVID-19
patients, it is still unclear whether the virus can infect the central nervous system, and which …