[HTML][HTML] Neuroinvasion and encephalitis following intranasal inoculation of SARS-CoV-2 in K18-hACE2 mice

P Kumari, HA Rothan, JP Natekar, S Stone, H Pathak… - Viruses, 2021 - mdpi.com
… in neurospheres and brain organoids infected with SARS-CoV-2 [18,19]. Human autopsy
reports … These data suggest that SARS-CoV-2 can productively infect human CNS cells [21]. …

How SARS-Cov-2 can involve the central nervous system. A systematic analysis of literature of the department of human neurosciences of Sapienza University, Italy

D Armocida, M Palmieri, A Frati, A Santoro… - Journal of Clinical …, 2020 - Elsevier
… lethal disease of a novel coronavirus renamed as SARS-CoV-2. SARS-CoV-2 shares highly
… The following search terms were used: SARS-Cov central nervous system, SARS-CoV brain

[PDF][PDF] SARS-CoV-2 infects neurons and induces neuroinflammation in a non-human primate model of COVID-19

D Beckman, A Bonillas, GB Diniz, S Ott, JW Roh… - Cell reports, 2022 - cell.com
… In this study, we aimed to establish whether SARS-CoV-2 can be detected in the brains of
rhesus monkeys during the acute phase of the infection by employing high-resolution three-…

Neuropilin‑1 as a new potential SARSCoV‑2 infection mediator implicated in the neurologic features and central nervous system involvement of COVID‑19

J Davies, HS Randeva, K Chatha… - Molecular …, 2020 - spandidos-publications.com
… Given the data by Cantuti-Castelvetri et al (17) showing that NRP1 may mediate the entry of
SARS-CoV-2 into the brain through the olfactory epithelium (17), our findings warrant further …

Antibody responses to SARS-CoV-2 short-lived

N Vabret - Nature Reviews Immunology, 2020 - nature.com
brain was highest at birth and then declined with age. Notably, similar observations were
made in studies using resected human brain … phenotype in the brain following entry from the …

Evidence of central nervous system infection and neuroinvasive routes, as well as neurological involvement, in the lethality of SARSCoV‐2 infection

JM Liu, BH Tan, S Wu, Y Gui, JL Suo… - Journal of medical …, 2021 - Wiley Online Library
… for SARS-CoV-2. Among 20 neuropathological studies reported so far, SARS-CoV-2 was
detected in the brain of … reported that SARS-CoV-2 could enter three-dimensional human brain

Brain exposure to SARS-CoV-2 virions perturbs synaptic homeostasis

E Partiot, A Hirschler, S Colomb, W Lutz, T Claeys… - Nature …, 2024 - nature.com
… We showed that SARS-CoV-2 exposure to the brain impacts electrical activity of whole
organoids using 3D MEAs. LFP recording of brain organoids is very challenging to monitor. Only …

Differential effects of SARS-CoV-2 variants on central nervous system cells and blood–brain barrier functions

A Proust, CJ Queval, R Harvey, L Adams… - Journal of …, 2023 - Springer
… We demonstrate that productive infection of brain cells is SARS-CoV-2 variant dependent
and … Lastly wild-type virus increases blood–brain barrier permeability and all variants, except …

SARS-CoV-2 causes brain inflammation and induces Lewy body formation in macaques

IH Philippens, KP Böszörményi, JA Wubben… - BioRxiv, 2021 - biorxiv.org
SARS-CoV-2 may cause acute respiratory disease, but the … Here we show that SARS-CoV-2
infection causes brain … in the brain, and viral RNA was detected in brain tissues from …

Neuroinvasion and neurotropism by SARS-CoV-2 variants in the K18-hACE2 mouse

F Seehusen, JJ Clark, P Sharma, EG Bentley, A Kirby… - Viruses, 2022 - mdpi.com
… a study using human brain organoids provided strong evidence that SARS-CoV-2 replicates
… report on 18 patients failed to detect SARS-CoV-2 antigen by immunohistochemical staining …