… the distal lung and associated inflammation. In this study, we develop primary human lung
… responses of proximal and distal lung epithelium to SARS-CoV-2 infection. Differentiated air-…

… SARS-CoV-2 and SARS-CoV infection of the human lungs, we treated ex vivo human lung
tissues with NA, followed by SARS-CoV-2 or SARS-CoV challenge. Our results showed that …

… coronavirus 2 (SARS-CoV-2) has caused a devastating pandemic. Although most people
infected with SARS-CoV-… cells are the progenitor cells of AT1 cells in the adult human lung 38 . …

… Clinically, SARS-CoV-2 infection may result in acute lung injury and … measured in human
epithelial cells after 24 h SARS-CoV-2 infection, or in existing datasets of lung fibrosis patients. …

… SARS-CoV-2 replication in Calu3 human lung cells with sub-micromolar 50% maximal effective
concentration (EC 50 ) and in primary human … of RDV in established human and monkey …

… changes and host response in the human lung induced by SARS-CoV-2 was almost never …
In this study, we used ex vivo human lung tissue challenged by SARS-CoV-2 with SARS-CoV …

… ) but are present in the human coronaviruses OC43, HKU1, and MERS-CoV (Figure 1C).
However, the contribution of this multibasic cleavage site to SARS-CoV-2 infection of human …

… SARS-CoV-2 for entry into lung cells 4 , renders SARS-CoV-2 … with SARS-CoV-2 in the
TMPRSS2-expressing human lung … in lung cells and is unlikely to protect against the spread of …

… We inoculated the human lung tissues of LoM with SARS-CoV-2, and determined titres of
replication-competent virus at 2, 6 and 14 days after exposure (Fig. 1c, Extended Data Table 2)…

… To correlate histopathological findings with sites of SARS-CoV-2 infection, we also
stained lung sections for viral RNA using in situ hybridization (Fig. 2b). At 2 dpi, expression of …