Immune profiling of plasma-derived extracellular vesicles identifies Parkinson disease

E Vacchi, J Burrello, D Di Silvestre… - Neurology …, 2020 - AAN Enterprises
Immune profiling of plasmatic EVs represents a crucial step toward the identification of
biomarkers of disease … according to the UK Parkinson's Disease Society Brain Bank criteria for …

[HTML][HTML] Parkinson's disease peripheral immune biomarker profile: a multicentre, cross-sectional and longitudinal study

Y Li, Y Yang, A Zhao, N Luo, M Niu, W Kang… - Journal of …, 2022 - Springer
… We showed a correlation between a profile of four peripheral immune biomarkers and PD
development and progression. Our findings may provide a basis whereby PD patients with …

[HTML][HTML] Transcriptional analysis of peripheral memory T cells reveals Parkinson's disease-specific gene signatures

R Dhanwani, JR Lima-Junior, A Sethi, J Pham… - … Parkinson's Disease, 2022 - nature.com
… IFNγ, IL-5, and IL-10 were chosen as markers of T cell reactivity as they capture a broad
immune … A key element in our study was to focus on the transcriptional profile of specific purified …

[HTML][HTML] Specific immune status in Parkinson's disease at different ages of onset

J Tian, SB Dai, SS Jiang, WY Yang, YQ Yan… - … Parkinson's Disease, 2022 - nature.com
immunity play a crucial role in Parkinson’s disease (PD). However, studies regarding specific
immune … Therefore, we aimed to explore the different immune status in patients with PD at …

[HTML][HTML] Immune cell activation in the cerebrospinal fluid of patients with Parkinson's disease

JB Schröder, M Pawlowski, G Meyer zu Hörste… - Frontiers in …, 2018 - frontiersin.org
… Methods: In this study, we performed comprehensive immune cell profiling in the … magnetic
resonance imaging, PB and CSF immune cell profiling by multiparameter flow cytometry, and …

[HTML][HTML] LRRK2 levels in immune cells are increased in Parkinson's disease

DA Cook, GT Kannarkat, AF Cintron… - … Parkinson's disease, 2017 - nature.com
… of the inflammatory environment characteristic of Parkinson’s disease. The aim of this …
immune cell subsets and correlate it with the immunophenotype of cells from Parkinson’s disease

[HTML][HTML] Immune profiling of Parkinson's disease revealed its association with a subset of infiltrating cells and signature genes

X Zhang, Z Shao, S Xu, Q Liu, C Liu, Y Luo… - Frontiers in Aging …, 2021 - frontiersin.org
… evidence revealed that peripheral immune cells might be … immune cells and signature genes
associated with immuneimmune cell infiltration and to identify the differential immune cell …

[HTML][HTML] Safety, tolerability, and immune-biomarker profiling for year-long sargramostim treatment of Parkinson's disease

KE Olson, KL Namminga, Y Lu, AD Schwab… - …, 2021 - thelancet.com
Background Neuroinflammation plays a pathogenic role in Parkinson's disease (PD).
Immunotherapies that restore brain homeostasis can mitigate neurodegeneration by transforming …

Parkinson disease and the immune system—associations, mechanisms and therapeutics

EK Tan, YX Chao, A West, LL Chan, W Poewe… - Nature Reviews …, 2020 - nature.com
immune system dysfunction has a role in Parkinson disease (PD… disease and PD, impaired
cellular and humoral immune … and evidence of immune dysregulation in experimental …

[HTML][HTML] Periphery and brain, innate and adaptive immunity in Parkinson's disease

AS Harms, SA Ferreira, M Romero-Ramos - Acta neuropathologica, 2021 - Springer
… The immune changes during the disease occur in the brain, involving microglia, but also in
… of the innate immune system, particularly monocytes, as well as those of adaptive immunity, …