T Follicular Helper (TFH) Cells in Normal and Dysregulated Immune Responses

C King, SG Tangye, CR Mackay - Annu. Rev. Immunol., 2008 - annualreviews.org
T follicular helper cells) are the true helper cells for Ab responses, although other T cells such
as Th2 cells, γδ T cells, and NKT cells … by suppressing the function of CD4 + CD57 − T cells

Transcriptional regulation of follicular T‐helper (Tfh) cells

X Liu, RI Nurieva, C Dong - Immunological reviews, 2013 - Wiley Online Library
… STAT5 efficiently inhibits Tfh differentiation by suppressing the expression of Tfh-associated
genes … Further understanding of Tfh cell regulation may offer ways to target various immune

IL-10–producing Tfh cells accumulate with age and link inflammation with age-related immune suppression

M Almanan, J Raynor, I Ogunsulire, A Malyshkina… - Science …, 2020 - science.org
cells that accumulate with age bore markers of Tfh cells, so, for clarity, we will refer to them as
Tfh10 cells… FoxP3 − CD4 + T cells, we blocked IL-6 after Tfh cells were formed in aged mice …

[HTML][HTML] CXCL13-producing TFH cells link immune suppression and adaptive memory in human breast cancer

C Gu-Trantien, E Migliori, L Buisseret, A de Wind… - JCI insight, 2017 - ncbi.nlm.nih.gov
… Our data suggest that human T FH X13 cell differentiation may be a key factor in converting
Treg-mediated immune suppression to de novo activation of adaptive antitumor humoral …

Control of TFH cell numbers: why and how?

A Pratama, CG Vinuesa - Immunology and cell biology, 2014 - Wiley Online Library
… c-Maf specifically in immune cells exhibited defective TFH cell differentiation in vivo. The c-…
-2 acting through STAT5 and IL-10 can suppress TFH cell development at least in mice. , 89 …

Cytokine-skewed Tfh cells: functional consequences for B cell help

AC Olatunde, JS Hale, TJ Lamb - Trends in immunology, 2021 - cell.com
… The heterogeneity of Tfh cells underscores their ability to modulate different humoral immune
… Regulatory T follicular (Tfr) cells can suppress T–B cell interactions through cytotoxic T …

Regulatory T cells control antigen-specific expansion of Tfh cell number and humoral immune responses via the coreceptor CTLA-4

JB Wing, W Ise, T Kurosaki, S Sakaguchi - Immunity, 2014 - cell.com
… This suggested that anti-CTLA-4 antibody treatment preferentially expanded tetramer-binding
Tfh cells out of proportion with their matching Tfr suppressive population, while PD1 + and …

T follicular helper (Tfh) cells in normal immune responses and in allergic disorders

G Varricchi, J Harker, F Borriello, G Marone… - Allergy, 2016 - Wiley Online Library
… for T follicular helper cells that parallels the development of other CD4 + T-cell lineages but
… Treg cells suppress the sensitization and effector phases of allergic reactions through the …

Mast cell-derived IL-10 suppresses germinal center formation by affecting T follicular helper cell function

R Chacón-Salinas, AY Limón-Flores… - The Journal of …, 2011 - journals.aai.org
… To analyze the role of mast cells in UV-induced immune suppression, we reconstituted
mast … We find that mast cells suppress Tfh cell generation, the formation of GCs, and Ab …

Follicular regulatory T cells repress cytokine production by follicular helper T cells and optimize IgG responses in mice

H Wu, Y Chen, H Liu, LL Xu, P Teuscher… - European journal of …, 2016 - Wiley Online Library
… whether Tfr cells could suppress the GCB cell response. … Tfh cells, this result of unchanged
GCB cell numbers in the absence of Tfr cells was observed after multiple types of immune