Statistical and integrative system-level analysis of DNA methylation data

AE Teschendorff, CL Relton - Nature Reviews Genetics, 2018 - nature.com
… Currently, DNA methylation is the only epigenetic mark that can … DNA methylation data,
including cell-type heterogeneity, feature selection, reverse causation and system-level analyses

Integrative analysis of DNA methylation and gene expression identified cervical cancer-specific diagnostic biomarkers

W Xu, M Xu, L Wang, W Zhou, R Xiang, Y Shi… - Signal transduction and …, 2019 - nature.com
… In this study, we analyzed DNA methylation and gene expression profiles in cervical cancer
… Unsupervised clustering analysis of DNA methylation profiles identified three methylation

Integrative analysis of DNA methylation and gene expression reveals hepatocellular carcinoma-specific diagnostic biomarkers

J Cheng, D Wei, Y Ji, L Chen, L Yang, G Li, L Wu… - Genome medicine, 2018 - Springer
… Our analyses showed that the cis-regulation of DNA methylation and gene expression was
… Compared with previously published methylation markers, our markers are the only ones …

Integrative analysis with expanded DNA methylation data reveals common key regulators and pathways in cancers

S Fan, J Tang, N Li, Y Zhao, R Ai, K Zhang… - NPJ genomic …, 2019 - nature.com
… We propose here an integrative analysis strategy to … DNA methylation data between normal
and cancer samples, we extracted the triple-evidenced genes for 13 cancers and analyzed

Integrative Analysis of DNA Methylation and Gene Expression Data Identifies EPAS1 as a Key Regulator of COPD

S Yoo, S Takikawa, P Geraghty, C Argmann… - PLoS …, 2015 - journals.plos.org
… Our first integrative analysis of genome-wide DNA methylation and gene expression
profiles illustrates that not only does DNA methylation play a ‘causal’ role in the molecular …

Integrative analysis of DNA methylation and gene expression reveals key molecular signatures in acute myocardial infarction

X Luo, Y Hu, J Shen, X Liu, T Wang, L Li, J Li - Clinical epigenetics, 2022 - Springer
… In summary, our study performed an integrative analysis of DNA methylation and mRNA
expression datasets deriving from AMI mouse models at series of time points to identify key …

[HTML][HTML] Integrative analysis of DNA methylation and gene expression to identify key epigenetic genes in glioblastoma

D Jia, W Lin, H Tang, Y Cheng, K Xu, Y He… - Aging (Albany …, 2019 - ncbi.nlm.nih.gov
… In the present study, we performed an integrative analysis of DNA methylation and gene
expression identified key epigenetic genes in GBM. The methylation and gene expression of …

Integrative analysis of DNA methylation and gene expression to determine specific diagnostic biomarkers and prognostic biomarkers of breast cancer

M Zhang, Y Wang, Y Wang, L Jiang, X Li… - Frontiers in Cell and …, 2020 - frontiersin.org
… Although previous studies have reported a cluster of aberrant promoter methylation … of these
DNA methylation changes. Here we aimed to identify specific DNA methylation signatures in …

An integrative cross-omics analysis of DNA methylation sites of glucose and insulin homeostasis

J Liu, E Carnero-Montoro, J van Dongen, S Lent… - Nature …, 2019 - nature.com
Despite existing reports on differential DNA methylation in type 2 diabetes (T2D) and obesity,
our understanding of its functional relevance remains limited. Here we show the effect of …

Integrative DNA methylation and gene expression analyses identify DNA packaging and epigenetic regulatory genes associated with low motility sperm

SE Pacheco, EA Houseman, BC Christensen… - PloS one, 2011 - journals.plos.org
… by performing integrative analysis of sperm DNA methylation and … analysis, we used a data
driven approach to first qualitatively assess associations among sperm DNA methylation and …