… We found that ORF10 also inhibits cGAS–STING-induced expression of IFN-β, IFN-λ1, …
reporter assays revealed that ORF10 suppressed STING-induced activation of IFN-β, IFN-λ1, and …

… overexpression of ORF10 downregulated the production of IFN-β … 2c, SARS-CoV-2 ORF10
downregulated the expression of … ORF10 downregulates RLR-mediated activation of the IFN …

… is activated in cells infected with SARS-CoV-2, that activation is … ORF10 genes, as well as
the SARS-CoV-2 structural Membrane (M) protein, which is reported to inhibit Type I and III IFN …

… that SARS-CoV-2 ORF3b protein is a potent interferon (IFN) … the cytoplasm to the nucleus,
blocking IFN activation (36). As … of ORF10 does not change replication ability of SARS-CoV-2, …

… The primary requirements for IFN-I transcriptional activation are the suppression of …
SARS-CoV-2 ORF10 overexpression blocks the expression of IFNs I and interferon-induced genes in …

… SARS-CoV-2 infection also induces the activation of TLR3 and Toll-like receptor 7 (TLR7)
RNA … Therefore, ORF10 suppresses the IFN signaling pathway by inhibiting MAVS expression …

… Thus, we were motivated to investigate the idea that ORF10 might … SARS-CoV-2–host
interactions. Pursuing this line of inquiry in the present study, we found that SARS-CoV-2 ORF10 …

… SARS-CoV-2 proteins that antagonize type I interferon (IFN-I) response. We found three
proteins that antagonize IFN-… the nucleus, activating the transcription of type I IFN (IFN-I) genes ( …

… , ORF6, ORF7a, ORF7b, ORF8, and ORF10) are infused between structural genes to code
for … , and N proteins of SARS-CoV-2 do not directly inhibit nor activate the IFN response (Fig. …

… However, successful viruses like SARS-CoV-2 have … SARS-CoV-2 uses many of its proteins
to counteract IFN induction and signaling, thus preventing effective innate immune activation…