… We identify two sets of viral proteins that antagonize IFN-I signaling through blocking signal
… , SARS-CoV-2 nsp1 and nsp6 suppress IFN-I signaling more efficiently than SARS-CoV and …

… by which SARS-CoV-2 evades innate immune recognition. More specifically, we explain
how this virus inhibits IFN signaling pathways (IFN-I/IFN-III) and controls interferon-stimulated …

… cell types and pathways that lead to IFN production as well as the importance of IFN timing
and … We will further discuss the mechanisms that SARS-CoV-2 uses to evade IFN responses, …

… pathways are shown in purple, whereas those that block components of the IFN signalling
pathway … for the high levels of IFN-I and IFN-III observed in response to SARS-CoV-2 infection, …

… in IFN responses.17, 19 Deficiencies in the IFN synthesis and response pathways can result
in increased COVID-19 … mechanisms of evasion of viral RNA recognition and IFN induction (…

… signaling pathways both upstream and downstream of IFN production. Moreover, we show
that SARS-CoV-2 is susceptible to IFN … into interactions between SARS-CoV-2 and the host. …

… antiviral IFN pathway is often a prime target for evasion of innate immune. Upon SARS-CoV-2 …
, experimental animals, and severe COVID-19 patients clearly suggest the extraordinarily …

… the IFN-mediated antiviral response in coronavirus … evasion by SARS-CoV and MERS-CoV.
Furthermore, we examine the role of type I and type III IFN response in SARS and MERS and …

… several mechanisms of SARS-CoV-2 innate immune evasion including suppression of
IFN-α/β … -I signaling SARS-CoV and SARS-CoV-2 express at least four molecules to escape …

… -PLpro could restore ISGylation of host proteins and was sufficient for SARS-CoV-2 infected
cells to recover their IFN-signaling and decrease the number of viral particles observed in …