[HTML][HTML] Early life adversity and neuropsychiatric disease: differential outcomes and translational relevance of rodent models

RC Waters, E Gould - Frontiers in systems neuroscience, 2022 - frontiersin.org
It is now well-established that early life adversity (ELA) predisposes individuals to develop
several neuropsychiatric conditions, including anxiety disorders, and major depressive …

Resilience priming: translational models for understanding resiliency and adaptation to early life adversity

AC Kentner, JF Cryan… - Developmental …, 2019 - Wiley Online Library
… Thoughts on the translational relevance of animal models of therapy, including environmental
enrichment, have been considered for decades; following the eighth Annual Winter …

[HTML][HTML] Improving translational relevance: the need for combined exposure models for studying prenatal adversity

BL Smith - Brain, Behavior, & Immunity-Health, 2021 - Elsevier
… or second exposure later in life, a translational approach would begin to … Animal models that
represent this translational context of … Finally, translational co-exposure models can identify …

Exposure to early adversity: Points of cross-species translation that can lead to improved understanding of depression

SL Andersen - Development and psychopathology, 2015 - cambridge.org
… to maltreatment from a translational viewpoint. Various paradigms of early life stress are …
cross-species comparisons are made in this paper with the goal of identifying translational

Translating basic research knowledge on the biological embedding of early-life stress into novel approaches for the developmental programming of lifelong health

CM Heim, S Entringer, C Buss - Psychoneuroendocrinology, 2019 - Elsevier
… that we can offer to victims of early adversity in order to efficiently prevent or reverse adverse
health outcomes. Such translational efforts can be expected to have significant impact on …

Neurobiology of early life stress and visceral pain: translational relevance from animal models to patient care

DK Prusator, A Andrews… - …, 2016 - Wiley Online Library
life stressful experiences by manipulation of the neonatal environment. These experimental
models have far reaching potential in translational … the influence of early life adversity on the …

Looking back and moving forward: Evaluating and advancing translation from animal models to human studies of early life stress and DNA methylation

SE Watamura, TL Roth - Developmental psychobiology, 2019 - Wiley Online Library
… two prominent models of early life adversity, the maternal … thorough evaluation of translational
relevance by allowing a … on subsequent adversity in the mother or child's life. One study …

Levers and barriers to success in the use of translational neuroscience for the prevention and treatment of mental health and promotion of well-being across the …

SR Horn, PA Fisher, JH Pfeifer, NB Allen… - Journal of abnormal …, 2020 - psycnet.apa.org
… the impact of adversity; Masten, 2001). A full account of the biological pathways linking early
adversity to … Translational neuroscience must identify relevant and malleable environmental, …

The three-hit concept of vulnerability and resilience: toward understanding adaptation to early-life adversity outcome

NP Daskalakis, RC Bagot, KJ Parker… - …, 2013 - Elsevier
relevance, the difference in the long-term outcome of the two paradigms asks for
standardization of methodology in animal studies of early-life adversity. In human studies, early-life

Developing an agenda for translational studies of resilience and vulnerability following trauma exposure

R Yehuda, JD Flory, S Southwick… - Annals of the New …, 2006 - Wiley Online Library
translational research agenda for studies of resilience, defined as the process of adapting well
in the face of adversity … revealed in this work to be as relevant as factors, such as cognitive …