… with exceptional human longevity at FDR < 10%. We … longevity and reveal a genetic overlap
between longevity and age-related diseases and traits. Beyond the study of human longevity…

… human populations. There are more than 100 candidate genes potentially involved in human
longevity; this … Linkage analysis is the traditional means of genetic mapping in humans. In …

… to highlight the most important conserved longevity- … pathways have been consistently
linked to longevity, namely (1) … studies on the genetics of human longevity should focus on the …

… of approaches are commonly used: linkage approaches and population-based association
… extended to human longevity research (Nebel and Schreiber 2005). Linkage analysis studies…

… While laboratory model work has shown major longevity effects of single genes or single
pathways, our results tend to support a model of human longevity influenced by multiple smaller …

… with exceptional longevity Genetic studies to date have focussed on linkage analysis, … -wide
association studies (GWAS) to identify exceptional longevity genes. In general, these have …

… In a search for longevity genes, centenarians and long-lived humans in general have
been the subject of extensive genetic linkage and/or association studies. Linkage analysis …

… Thus, the old approach of linkage analysis when combined with the new technologies of
high massive re- sequencing could produce novel and interpretable results. Re-sequencing …

… longevity in humans are modulated by a lucky combination of genetic and non-genetic factors.
Family studies demonstrated that about 25 % of the variation in human longevity … longevity…

… analyze the combined effect of a SNP set grouped per pathway or gene region. We used this
approach to study the joint effect on human longevity … For the analyses, we used genotyped …