… Human longevity is heritable, but genome-wide association (… perform two meta-analyses of
GWA studies of a rigorous longevity … Gene-level association analysis reveals a role for tissue-…

… meta-analysis show that PON1 gene variants at codon 192 impact on the probability of attaining
longevity… finding is the rule in the studies on the genetics of human longevity 9 . A careful …

… However, to date, genetic studies examining exceptional longevity have been inconclusive.
… the genetic variants associated with exceptional longevity by undertaking meta-analyses. …

… Although this study represents the largest meta-analysis of exceptional longevity to date,
the overall sample size is still relatively small to capture small genetic effects. The LLFS set is …

… a subset analysis in cases aged ≥90 years. The novel longevity locus we identified was
tested for association with prospective (cause-specific) mortality in a meta-analysis of 11 …

… to genetic studies of longevity using … genes for longevity by GWAS? It has been argued that
it may require a great number of ‘protective’ genes all with very small effects to have a genetic …

… part of the GTCT haplotype associated with greater longevity in our meta-analysis. Another
SNP in our reported haplotype, rs915179, associated with longevity in a recent genome-wide …

… of how a meta-analysis can inflate the false negative rates of genetic association studies
or it can bias estimates of the association between a genetic variant and extreme longevity. …

… Cross-validation of candidate genes We next attempted to validate 13 candidate genes
identified in previous longevity studies. In our study, only three of these genes showed …

… The objective of this meta-analysis was to determine the association of the apolipoprotein
E (ApoE) gene with exceptional longevity (EL) (ie., reaching 100+ years) by identifying …