… genetic variation in genes involved in the IIS and TM pathways is associated with human
longevity… TM pathways with longevity, we also investigated the association of gene SNP sets …

… the relationships between groups of genes regulated by both longevity and aging, we
performed a meta-analysis on whole-genome hepatic gene expression changes in mice and …

… , longevity assurance pathway In the quest of human longevity genes, genes involved in
the … with AD and CAD, respectively, in a set of genes was also replicated in this meta-analysis. …

… We test a specific set of candidate longevity genes—identified by comparative functional
genomics—in humans in relation to non-cognitive psychological traits and states. Haplotype-…

… Klotho gene and human aging and longevity. We used a meta-analytic approach to quantitatively
synthesize the possible effect of the variant and to reconcile the study inconsistencies. …

… , the sex-specific GWAS (stage 1) provides candidate sex-specific loci, and our conclusions
of reconfirmed sex-specific longevity loci are mainly based on the PRS analyses (stage 2). …

… to women, leading to a comparatively high longevity in women [14]. The application of the …
to promote the age longevity related genes. Overall, 115 aging associated genes have been …

… consistent with our earlier findings of the genetics of extreme human longevity through
GWAS and sequencing that identified a cluster of significant SNPs in the MHC complex (21,38). …

… approach found longevity genes conserved … longevity genes influence variance in cognitive
ability and age-related cognitive decline in humans. Here, we investigated six of these genes …

… and disease study, let S be the total number of SNPs, and for each SNP s let be its Z
score (standard score) for association with disease (from the meta analysis). Given , we can …