… Third, in this analysis we did not examine epistasis or gene-environment interactions which
may modify the associations in this study. Importantly, this study is hypothesis generating. …

… not seem to compromise longevity. Here we argue that trade-off-like and conditional effects
of genes can play central role in this phenomenon and in determining longevity. Such effects …

… longevity determinants in human populations. The knowledge of such determinants, genetic
… the future of human longevity genetics we argue that, beyond gene-environment interaction (…

… in the aging of the cardiovascular system and in longevity. … In this meta-analysis of GWAS
results from six observational … and TERC, two intrinsic telomere maintenance genes. We, also, …

… blood donors were similar for all polymorphisms, and this study suggests that common
variations in genes associated with cardiovascular risk do not contribute significantly to longevity. …

… consistent associations with longevity in diverse human … , and thus healthy ageing and
longevity. Methods: The study … : We review the molecular genetics of FOXO3 in longevity, then …

… We will first discuss the efforts to identify longevity loci by genetics approaches. … established
as a longevity gene. Several other loci showed suggestive association with longevity (p < 5 × …

… we compare the gene expression trend of anti- and pro-longevity genes to the general … of
the most interesting genes identified in this analysis. For example, the anti-longevity gene SHC-…

… with longevity in a comparison of long-lived Ashkenazi Jews and their offspring with younger
controls. Genetic … (SNPs) in the TERC and TERT genes and TL. Other studies reported …

… Our case-control data indicated that CETP 405V is a longevity risk allele in all genetic … for
meta-analysis, which confirmed 405V is the risky allele against longevity in all genetic models: …