… longevity and age at death. By using three different genetic models and two definitions of
extreme longevity … a substantially decreased odds for extreme longevity, and increased risk for …

… or less increases in lifespan realized via genetic or dietary manipulations of laboratory mice.
… a single gene while leaving expression of important complementary genes unchanged. And …

… known longevity- and Alzheimer’s disease-associated loci APOE and TOMM40. We propose
this region as a longevity hub, operating on both a genetic … and associated gene expression …

… the previously reported longevity locus cyclin… longevity cohort was only successful for
rs1063192 in CDKN2B-AS1. In conclusion, we identified 2 new potential candidate longevity genes…

… meta-analysis has revealed novel age-related genes, setting … and functional meta-analysis,
we tried to identify genes whose … Our analyses revealed that HDFs and T-cells share 11 …

… the genes involved in longevity, a topic that has been addressed recently (3–5), but to highlight
the overlap between the genetics of longevity and the genetics of … this type of analysis; we …

… Compared wide-type nematodes, loss-of-function mutation of daf-16 and daf-18 gene resulted
in lower longevity, while opposite results were observed for daf-2, age-1, akt-1 and akt-2 …

… We also report 21 Horvath-EAA-associated genes including … ), and implicated 12 genes
including several involved in innate … Both measures had nominal inverse genetic correlations …

… diseases, genetic factors may also promote extreme longevity. … the genetic variation underlying
the genetic component. Persons who attain extreme old age might simply lack the genetic …

… To evaluate the genetic correlations between longevity and complex diseases/traits, we …
selected GWAS meta-analysis summary statistics of complex diseases/traits, to predict longevity. …