… In conclusion, comprehensive targeted methylation sequencing of over 9000 … cancers
predicts the presence of cancer and underlying tumor type with high accuracy, and methylation …

… an ultrasensitive cancer detection method, termed ‘CancerDetector’, using the DNA methylation
… The key of our method is to probabilistically model the joint methylation states of multiple …

… Moreover, novel technological breakthroughs such as long read sequencing and … enhancing
cancer management and improving early disease detection. DNA methylation alterations …

… These results provided the first direct evidence that methylation biomarkers can be used for
cancer detection in asymptomatic individuals. Later, breast cancer was detected in serum as …

… the sequence reads to a genomic reference, methylation rate … of epigenetic changes in
cancer detection and monitoring. … during carcinogenesis is de novo methylation of CpG islands, …

… This study assessed gene methylation using the bisulfite sequencing method and high-resolution
melting curve analysis in the serum of 36 patients with breast ductal carcinoma, 30 …

… Methylated sequences can also be detected by the re-expression of genes after treatment
of cells with a demethylating agent. These procedures are usually combined with genome-…

… signatures carried in ctDNA for early-stage lung cancer detection, we enrolled 192 patients
and 10 ml of plasma was collected from each patient before surgery. 13 samples were …

… detection of cancer.17, 18, 19 To keep improving the performance of cfDNA methylation in
cancer detection… may advance the applicability of cfDNA methylation in multi-cancer detection. …

… Although Methylscape showed lower cancer detection accuracy than the other
sequencing-based assay described above, its simple methodology enables reduction of sample …