Longitudinal study of DNA methylation and epigenetic clocks prior to and following test-confirmed COVID-19 and mRNA vaccination

APS Pang, AT Higgins-Chen, F Comite, I Raica… - Frontiers in …, 2022 - frontiersin.org
mRNA COVID-19 vaccination upon epigenetic clocks by obtaining DNA methylation profiles
from blood of participants prior to and following mRNA COVID-19 vaccinationmRNA vaccine

[HTML][HTML] COVID-19 subgroups may slow down biological age acceleration

Y Guo, Y Zhang, Y Hu - The Journal of Infection, 2023 - ncbi.nlm.nih.gov
epigenetic clocks measure epigenetic age acceleration differently in terms of their CpGs
components, they all have been shown to assess epigenetic … effect of epigenetic clocks on three …

A cautionary note on altered pace of aging in the COVID-19 era

MAH Attia - Forensic Science International: Genetics, 2022 - Elsevier
… These epigenetic modifications have been linked to perturbations to the epigenetic clock, …
by Moderna mRNA vaccine by 3.9 years in average in the same age group presenting with …

How to slow down the ticking clock: age-associated epigenetic alterations and related interventions to extend life span

AM Galow, S Peleg - Cells, 2022 - mdpi.com
… the so-called GrimAge clock [86]. An overview of all major epigenetic clocks in humans and
… Of note, data exploration applying several existing epigenetic clocks has been facilitated for …

[HTML][HTML] An evidence-based debate on epigenetics and immunosenescence in COVID-19

C Napoli, E Coscioni, U Trama, MG Strozziero… - Current Research in …, 2023 - Elsevier
… “epigenetic age” based on DNA methylation profiles at specific genomic sites (epigenetic
clock). Some large prospective studies showed that the acceleration of epigenetic aging as …

The emerging role of epigenetics in the immune response to vaccination and infection: a systematic review

S Bannister, NL Messina, B Novakovic, N Curtis - Epigenetics, 2020 - Taylor & Francis
… -α promoter and increased TNF-α messenger RNA (mRNA) in whole blood compared with
uninfected … The ‘epigenetic clock’ is a validated biomarker of ageing that comprises a linear …

A methylation clock model of mild SARS‐CoV‐2 infection provides insight into immune dysregulation

W Mao, CM Miller, VD Nair, Y Ge… - Molecular Systems …, 2023 - embopress.org
… We note that the SARS-CoV-2 vaccine was not available at … the epigenetic state we identify
is distinct from trained immunity. … Briefly, mRNA was isolated from purified 300 ng total RNA …

Invited Commentary: Epigenetic Clocks and Obesity—Towards the Next Frontier Using Integrative Approaches and Early-Life Models

F Tekola-Ayele - American Journal of Epidemiology, 2021 - academic.oup.com
… markers, known as epigenetic clocks, are facilitating these … and the ticking rate of epigenetic
clocks in blood. This … complex relationship between obesity and epigenetic aging. The early-…

Responders and non-responders to influenza vaccination: A DNA methylation approach on blood cells

N Gensous, C Franceschi, BB Blomberg… - Experimental …, 2018 - Elsevier
… impacts susceptibility to influenza and responsiveness to influenza vaccine (Yao et al.,
2011). Here we used Horvath's epigenetic clock to estimate the DNA methylation age (DNAmAge…

Chronovaccination: Harnessing circadian rhythms to optimize immunisation strategies

CO Otasowie, R Tanner, DW Ray, JM Austyn… - Frontiers in …, 2022 - frontiersin.org
… that time of day of vaccination with the Pfizer mRNA or Oxford-… molecular clocks in cells
(coordinated by the central clock in the … Interestingly, epigenetic differences resulting in increased …