… metabolic regulators impact on proteostasis mechanisms. Both, metabolic imbalance and
proteostatic decline are causally linked to aging and aging-associated pathologic disorders (…

… Maintenance of protein homeostasis, or proteostasis, is … the multidimensional nature of the
proteostasis networks, which allow … age-associated diseases when they malfunction in aging. …

… aging have turned the attention toward the therapeutic opportunities offered by the restoration
of proteostasis in age-… Here, we discuss some of the unresolved questions on proteostasis …

… Although a number of stress response pathways can greatly influence proteostasis, aging,
and disease (see the sidebar), here we focus our attention on the HSR, which is regulated by …

… cells, mainly responsible for proteostasis, as well as the “… Many age-related pathologies
and the aging process itself … and the effects of aging on proteostasis in mammalian cells. …

… In this Review, we discuss our present understanding of the organization of the proteostasis
network and its role in health and disease. We describe the age-dependent changes in the …

… of aging with focus on proteostasis. We present how changes in components of proteostasis,
during aging, impact … of aging biomarkers and discuss the potential of proteostasis network …

… regarding tissue aging having a dramatic impact in overall metabolism and homeostasis. …
This review summarizes the effects of the loss of proteostasis during muscle aging. It is clear …

The article Build-UPS and break-downs: metabolism impacts on proteostasis and aging,
written by Franziska Ottens, André Franz, Thorsten Hoppe, was originally published …

… mitochondrial proteostasis, contributes to tissue dysfunction and negatively impacts systemic
… of mitochondrial proteostasis and how those mechanisms change with age is important for …