Psychiatric disorders, morbidity, and mortality: tracing mechanistic pathways to accelerated aging

JK Kiecolt-Glaser, SJ Wilson - Psychosomatic medicine, 2016 - journals.lww.com
… Individuals with higher levels of epigenetic aging relative to their actual age had a higher …
aging acceleration with frailty ( 31 ). Other researchers showed that greater age acceleration

Transdiagnostic evaluation of epigenetic age acceleration and burden of psychiatric disorders

N Yusupov, L Dieckmann, M Erhart, S Sauer… - …, 2023 - nature.com
… risk conferred by comorbid psychiatric disorder on BA and thus age-associated disease. …
of mood and anxiety disorders. Stronger associations with age-associated diseases and …

[HTML][HTML] Accelerated biological aging in serious mental disorders

OM Wolkowitz - World Psychiatry, 2018 - ncbi.nlm.nih.gov
accelerated biological aging in SMDs is supported by reports of acceleration of certain
biomarkers of age, such as leukocyte telomere length2 and epigenetic age4. However, data on …

Associations of stress and stress-related psychiatric disorders with GrimAge acceleration: review and suggestions for future work

E Protsenko, OM Wolkowitz, K Yaffe - Translational psychiatry, 2023 - nature.com
… Research questions about the causal relationship between a psychiatric exposure and
epigenetic age acceleration require the same considerations. However, unlike with morbidity and …

[HTML][HTML] Epigenetic age acceleration as a biomarker for impaired cognitive abilities in adulthood following early life adversity and psychiatric disorders

JM Felt, N Yusupov, KD Harrington, J Fietz… - Neurobiology of …, 2023 - Elsevier
age acceleration was associated with neurocognitive functioning in a sample with independent
substantiation of child sexual abuse and in a sample recruited for psychiatric disorder

Accelerated brain aging in schizophrenia and beyond: a neuroanatomical marker of psychiatric disorders

N Koutsouleris, C Davatzikos, S Borgwardt… - Schizophrenia …, 2014 - academic.oup.com
… to individually estimate age from the structural … accelerated aging” effect may particularly
impact on the neuroanatomical signature of SZ but may extend also to other mental disorders

Major depressive disorder and accelerated cellular aging: results from a large psychiatric cohort study

JE Verhoeven, D Révész, ES Epel, J Lin… - … psychiatry, 2014 - nature.com
… Evidence for the construct validity of the CTI has been collected in numerous studies showing
that CTI scales are related to the prevalence, incidence and course of psychiatric disorder. …

Brain age in mood and psychotic disorders: a systematic review and meta‐analysis

PL Ballester, MT Romano… - Acta Psychiatrica …, 2022 - Wiley Online Library
… We hypothesized that SCZ, BD, and MDD would all present signs of accelerated brain aging
with … major psychiatric disorders the brain age gap would be positively associated with age. …

Childhood psychiatric disorders as anomalies in neurodevelopmental trajectories

P Shaw, N Gogtay, J Rapoport - Human brain mapping, 2010 - Wiley Online Library
… autism, there was an infantile rapid acceleration of brain growth both in gray matter …
acceleration started around 1 year. The accelerated growth was dysregulated as by 2 years of age

Association of treatable health conditions during adolescence with accelerated aging at midlife

KJ Bourassa, TE Moffitt, A Ambler, AR Hariri… - JAMA …, 2022 - jamanetwork.com
… biological age during midlife. Identifying the conditions associated with accelerated biological
age … , and psychological disorders would be associated with older biological age at midlife. …