Association of epigenetic age acceleration with incident mild cognitive impairment and dementia among older women

AH Shadyab, LK McEvoy, S Horvath… - The Journals of …, 2022 - academic.oup.com
age acceleration (IEAA) was developed using the Horvath clock (12), which uses 353 CpGs
to define DNAm age… ; AgeAccelPheno = epigenetic age acceleration according to PhenoAge …

Translating developmental neuroscience to understand risk for psychiatric disorders

HC Meyer, FS Lee - American Journal of Psychiatry, 2019 - Am Psychiatric Assoc
… time frame in which the majority of psychiatric disorders emerge. Recent efforts to identify …
, to identify brain circuit alterations in psychiatric disorders that frequently emerge in developing …

Dimensions of childhood adversity differentially affect biological aging in major depression

R Rampersaud, E Protsenko, R Yang, V Reus… - … psychiatry, 2022 - nature.com
age, several studies have demonstrated a link between the cumulative exposure to childhood
adversities and accelerated … is associated with epigenetic age acceleration (EAA) using …

Early experiences of threat, but not deprivation, are associated with accelerated biological aging in children and adolescents

JA Sumner, NL Colich, M Uddin, D Armstrong… - … psychiatry, 2019 - Elsevier
… associated with epigenetic age acceleration in our sample, and we … psychiatric disorders
in the national comorbidity survey replication I: Associations with first onset of DSM-IV disorders

Estimating accelerated biological ageing using machine learning and metabolomics data in people with mental disorders

J Mutz, CM Lewis - European Psychiatry, 2023 - search.proquest.com
disorders were biologically older than their chronological age. … with psychiatric disorders
C. Manso-Bazús1*, N. Spataro2, L. … Introduction: Psychiatric disorders are more prevalent in …

Accelerated epigenetic aging in suicide attempters uninfluenced by high intent-to-die and choice of lethal methods

J Jokinen, P Andersson, A Chatzittofis, J Savard… - … psychiatry, 2022 - nature.com
acceleration conferred by any suicide attempt was not feasible. Studies including matched
non-suicidal psychiatric … differences in any psychiatric disorder necessitating the prescription …

[HTML][HTML] Internalizing symptoms associate with the pace of epigenetic aging in childhood

MS Tollenaar, R Beijers, E Garg, TTT Nguyen… - Biological …, 2021 - Elsevier
psychiatric symptoms may be associated with advanced biological aging. This study examined
whether epigenetic age acceleration (… the association between psychiatric disorders and …

Traumatic stress, oxidative stress and post-traumatic stress disorder: neurodegeneration and the accelerated-aging hypothesis

MW Miller, N Sadeh - Molecular psychiatry, 2014 - nature.com
Post-traumatic stress disorder (PTSD) is associated with elevated risk for a variety of age-related
diseases and neurodegeneration. In this paper, we review evidence relevant to the …

Is depression associated with accelerated aging? Mechanisms and implications

D Lindqvist, NM Simon, OM Wolkowitz - Neurobiology of Depression, 2019 - Elsevier
… 0.59 Shorter LTL in MDD Psychiatric: This study excluded subjects with manic, … disorders,
and dementia. But they did include patients with other (unspecified) psychiatric disorders

DNA methylation evidence against the accelerated aging hypothesis of schizophrenia

BC McKinney, H Lin, Y Ding, DA Lewis, RA Sweet - npj Schizophrenia, 2017 - nature.com
… Leukocyte telomere length has been investigated in multiple psychiatric disorders, including
SZ. Notably, the results suggest that, if present in SZ, biological age acceleration is modest …