Chronic Obstructive Pulmonary Disease, inflammation and co-morbidity–a common inflammatory phenotype?

MJ Sevenoaks, RA Stockley - Respiratory research, 2006 - Springer
… roles of inflammation and these pro-inflammatory cytokines … proposes a common inflammatory
TNF-α phenotype that may… the greater pro-inflammatory phenotype expressing CaGA was …

Pulmonary infection by SARS-CoV-2 induces senescence accompanied by an inflammatory phenotype in severe COVID-19: possible implications for viral …

K Evangelou, D Veroutis, K Paschalaki… - European …, 2022 - Eur Respiratory Soc
… Conclusions We demonstrate that in severe COVID-19, AT2 cells infected by SARS-CoV-2 …
phenotype. In vitro, SARS-CoV-2 infection induces senescence and inflammation. Importantly…

Characteristics of inflammatory phenotypes in patients with chronic obstructive pulmonary disease: a cross-sectional study

X Wen, Z Deng, J Peng, H Yang… - BMJ Open …, 2023 - bmjopenrespres.bmj.com
… airway inflammation in chronic obstructive pulmonary disease (… to investigate the airway
inflammatory phenotypes in COPD … Classification of airway inflammation phenotypes was based …

Pulmonary exacerbation inflammatory phenotypes in adults with cystic fibrosis

K Dong, SM Huh, GY Lam, J Jang, AN Franciosi… - Journal of Cystic …, 2023 - Elsevier
… adults with PEx demonstrating a pauci-inflammatory phenotype might derive less clinical
benefit from IV antibiotic treatment than patients with other systemic inflammatory phenotypes. …

Acute pulmonary exacerbation phenotypes in patients with cystic fibrosis

SC Carter, AN Franciosi, KM O'Shea… - Annals of the …, 2022 - atsjournals.org
… To define a pauci-inflammatory phenotype we used the absence of viral infection and an
elevation of CRP. Elevation in CRP may occur with exacerbation, but we acknowledge that …

Mechanisms and impact of the frequent exacerbator phenotype in chronic obstructive pulmonary disease

JA Wedzicha, SE Brill, JP Allinson, GC Donaldson - BMC medicine, 2013 - Springer
… exacerbator phenotype is complex, with increased airway and systemic inflammation, …
and a possible increased susceptibility to viral infection. Frequent exacerbators are also at …

Inflammatory mechanisms in patients with chronic obstructive pulmonary disease

PJ Barnes - Journal of Allergy and Clinical Immunology, 2016 - Elsevier
inflammatory protein release from senescent cells in the lung. In the future, it will be important
to recognize phenotypes of … that identify the therapeutic phenotypes will be important. …

Chronic obstructive pulmonary disease phenotypes, biomarkers, and prognostic indicators.

CE Brightling - Allergy & Asthma Proceedings, 2016 - search.ebscohost.com
… Remodeling in response to infection and injury. Airway inflammation and hypersecretion
of mucus in smoking subjects with chronic ob structive pulmonary disease. Am J Respir Crit …

Azithromycin Alters Macrophage Phenotype and Pulmonary Compartmentalization during Lung Infection with Pseudomonas

DJ Feola, BA Garvy, TJ Cory, SE Birket… - Antimicrobial agents …, 2010 - Am Soc Microbiol
… The properties of macrophage activation, immune cell infiltration, and markers of pulmonary
inflammation in the lung interstitial and alveolar compartments were evaluated postinfection. …

[HTML][HTML] Chronic bronchial infection in COPD. Is there an infective phenotype?

Z Matkovic, M Miravitlles - Respiratory medicine, 2013 - Elsevier
… , in the pathogenesis of chronic obstructive pulmonary disease (COPD) has been the focus
… different phenotypes. Bacterial exacerbations present with a particular inflammatory profile …