An efficient, generalizable method for genome-wide mapping of single-cell histone
modifications or chromatin-binding proteins is lacking. Here, we develop CoBATCH …

Recent technological advances have enabled massively parallel chromatin profiling with
scATAC-seq (single-cell assay for transposase accessible chromatin by sequencing). Here …

In contrast to single-cell approaches for measuring gene expression and DNA accessibility,
single-cell methods for analyzing histone modifications are limited by low sensitivity and …

Chromatin profiling at locus resolution uncovers gene regulatory features that define cell
types and developmental trajectories, but it remains challenging to map and compare …

Deciphering mechanisms in cell-fate decisions requires single-cell holistic reconstructions of
multidimensional epigenomic states in transcriptional regulation. Here we develop CoTECH …

Methods for quantifying gene expression and chromatin accessibility in single cells are well
established, but single-cell analysis of chromatin regions with specific histone modifications …

Genome-wide profiling of histone modifications can reveal not only the location and activity
state of regulatory elements, but also the regulatory mechanisms involved in cell-type …

INTRODUCTION In recent years, the single-cell genomics field has made incredible
progress toward disentangling the cellular heterogeneity of human tissues. However, the …

Chromatin profiling provides a versatile means to investigate functional genomic elements
and their regulation. However, current methods yield ensemble profiles that are insensitive …

Modern next-generation sequencing-based methods have empowered researchers to assay
the epigenetic states of individual cells. Existing techniques for profiling epigenetic marks in …