Aging is a complex process involving transcriptomic changes associated with deterioration
across multiple tissues and organs, including the brain. Recent studies using heterochronic …

Heterochronic parabiosis (HPB) is known for its functional rejuvenation effects across
several mouse tissues. However, its impact on biological age and long-term health is …

The ability to slow or reverse biological ageing would have major implications for mitigating
disease risk and maintaining vitality. Although an increasing number of interventions show …

The young circulatory milieu capable of delaying aging in individual tissues is of interest as
rejuvenation strategies, but how it achieves cellular-and systemic-level effects has remained …

Vascular aging has a central role in the pathogenesis of cardiovascular diseases
contributing to increased mortality of older adults. There is increasing evidence that, in …

The diversity of cell types is a challenge for quantifying aging and its reversal. Here we
develop 'aging clocks' based on single-cell transcriptomics to characterize cell-type-specific …

An increase in the burden of senescent cells in tissues with age contributes to driving aging
and the onset of age-related diseases. Genetic and pharmacologic elimination of senescent …

The mammalian brain is complex, with multiple cell types performing a variety of diverse
functions, but exactly how each cell type is affected in aging remains largely unknown. Here …

Age-related impairment of neurovascular coupling (NVC;“functional hyperemia”) is a critical
factor in the development of vascular cognitive impairment (VCI). Recent geroscience …

Aging is strongly correlated with decreases in neurogenesis, the process by which neural
stem and progenitor cells proliferate and differentiate into new neurons. In addition to stem …