Identifying the systems-level mechanisms that lead to Alzheimer's disease, an unmet need,
is an essential step toward the development of therapeutics. In this work, we report that the …

In recent years, significant advancements have been made in understanding Alzheimer's
disease from both neurobiological and clinical perspectives. Exploring the complex systems …

Alzheimer's disease (AD) is a pervasive, relentlessly progressive neurodegenerative
disorder that includes both hereditary and sporadic forms linked by common underlying …

Alzheimer's disease (AD) is a disabling neurodegenerative disorder that leads to long-term
functional and cognitive impairment and greatly reduces life expectancy. Early genetic …

Alzheimer's disease is a progressive, neurodegenerative disease that represents a growing
global health crisis. Two major forms of the disease exist: early onset (familial) and late …

The search for the genetic factors contributing to Alzheimer disease (AD) has evolved
tremendously throughout the years. It started from the discovery of fully penetrant mutations …

Early-onset, familial Alzheimer's disease (AD) is rare and may be attributed to disease-
causinq mutations. By contrast, late onset, sporadic (non-Mendelian) AD is far more …

Alzheimer's disease, the commonest cause of dementia, is a growing global health concern
with huge implications for individuals and society. In this review, current understanding of …

Abstract A strong genetic predisposition (60–80% of attributable risk) is present in
Alzheimer's disease (AD). In view of this major genetic component, identification of the …

Alzheimer's disease (AD) is a complex neurodegenerative disease, affecting a significant
part of the population. The majority of AD cases occur in the elderly with a typical age of …