Advances in lipid nanoparticles for mRNA-based cancer immunotherapy

ML Guevara, F Persano, S Persano - Frontiers in chemistry, 2020 - frontiersin.org
Over the past decade, messenger RNA (mRNA) has emerged as potent and flexible platform
for the development of novel effective cancer immunotherapies. Advances in non-viral gene …

Recent advancements in lipid–mRNA nanoparticles as a treatment option for cancer immunotherapy

P Karmacharya, BR Patil, JO Kim - Journal of pharmaceutical investigation, 2022 - Springer
Background Cancer remains a serious health concern worldwide, and different approaches
are being developed for its treatment. The strategy to use the immune system as an …

Lipid nanoparticle-based mRNA delivery systems for cancer immunotherapy

J Han, J Lim, CPJ Wang, JH Han, HE Shin, SN Kim… - Nano …, 2023 - Springer
Cancer immunotherapy, which harnesses the power of the immune system, has shown
immense promise in the fight against malignancies. Messenger RNA (mRNA) stands as a …

From structural design to delivery: mRNA therapeutics for cancer immunotherapy

F Zhou, L Huang, S Li, W Yang, F Chen, Z Cai… - …, 2024 - Wiley Online Library
Abstract mRNA therapeutics have emerged as powerful tools for cancer immunotherapy in
accordance with their superiority in expressing all sequence‐known proteins in vivo. In …

[HTML][HTML] mRNA: A promising platform for cancer immunotherapy

B Kong, Y Kim, EH Kim, JS Suk, Y Yang - Advanced Drug Delivery Reviews, 2023 - Elsevier
Messenger RNA (mRNA) is now in the limelight as a powerful tool for treating various
human diseases, especially malignant tumors, thanks to the remarkable clinical outcomes of …

Delivering the right message: Challenges and opportunities in lipid nanoparticles-mediated modified mRNA therapeutics—An innate immune system standpoint

Y Granot, D Peer - Seminars in immunology, 2017 - Elsevier
Abstract mRNA molecules hold tremendous potential as a tool for gene therapy of a wide
range of diseases. However, the main hurdle in implementation of mRNA for therapeutics …

Lipid nanoparticle-based mRNA candidates elicit potent T cell responses

Y Zeng, O Escalona-Rayo, R Knol, A Kros… - Biomaterials …, 2023 - pubs.rsc.org
The induction of a potent T cell response is essential for successful tumor immunotherapy
and protection against many infectious diseases. In the past few years, mRNA vaccines …

Lipid nanoparticle assisted mRNA delivery for potent cancer immunotherapy

MA Oberli, AM Reichmuth, JR Dorkin, MJ Mitchell… - Nano …, 2017 - ACS Publications
The induction of a strong cytotoxic T cell response is an important prerequisite for successful
immunotherapy against many viral diseases and tumors. Nucleotide vaccines, including …

Development and applications of mRNA treatment based on lipid nanoparticles

Z Wang, W Ma, X Fu, Y Qi, Y Zhao, S Zhang - Biotechnology Advances, 2023 - Elsevier
Nucleic acid-based therapies such as messenger RNA have the potential to revolutionize
modern medicine and enhance the performance of existing pharmaceuticals. The key …

Targeting cancer with mRNA–lipid nanoparticles: key considerations and future prospects

E Kon, N Ad-El, I Hazan-Halevy… - Nature reviews clinical …, 2023 - nature.com
Harnessing mRNA–lipid nanoparticles (LNPs) to treat patients with cancer has been an
ongoing research area that started before these versatile nanoparticles were successfully …