Can an effective SARS-CoV-2 vaccine be developed for the older population?

G Pawelec, N Weng - Immunity & Ageing, 2020 - Springer
The emergence of SARS-CoV-2 and its inordinately rapid spread is posing severe
challenges to the wellbeing of millions of people worldwide, health care systems and the …

COVID-19 in the elderly people and advances in vaccination approaches

K Dhama, SK Patel, S Natesan, KS Vora… - Human vaccines & …, 2020 - Taylor & Francis
The rapid worldwide spread of the COVID-19 pandemic, caused by the newly emerged
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in tens of …

Shelter from the cytokine storm: pitfalls and prospects in the development of SARS-CoV-2 vaccines for an elderly population

A Ciabattini, P Garagnani, F Santoro… - Seminars in …, 2020 - Springer
The SARS-CoV-2 pandemic urgently calls for the development of effective preventive tools.
COVID-19 hits greatly the elder and more fragile fraction of the population boosting the …

Covid-19 and immunity in aging populations—a new research agenda

WC Koff, MA Williams - New England Journal of Medicine, 2020 - Mass Medical Soc
Covid-19 and Immunity in Aging Populations As billions of dollars flow into research and
development efforts aimed at controlling SARS-CoV-2, the pandemic response remains …

The impact of immuno-aging on SARS-CoV-2 vaccine development

J Connors, MR Bell, J Marcy, M Kutzler, EK Haddad - Geroscience, 2021 - Springer
The SARS-CoV-2 pandemic has almost 56 million confirmed cases resulting in over 1.3
million deaths as of November 2020. This infection has proved more deadly to older adults …

Aging in COVID-19: Vulnerability, immunity and intervention

Y Chen, SL Klein, BT Garibaldi, H Li, C Wu… - Ageing research …, 2021 - Elsevier
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic was first
reported in Wuhan, China in December 2019, moved across the globe at an unprecedented …

Unanticipated efficacy of SARS-CoV-2 vaccination in older adults

G Pawelec, J McElhaney - Immunity & Ageing, 2021 - Springer
The rapidity with which vaccines against COVID-19 have been developed and tested is
unprecedented. As classically the case with randomized clinical trials, many studies …

SARS-CoV-2 and COVID-19 in older adults: what we may expect regarding pathogenesis, immune responses, and outcomes

J Nikolich-Zugich, KS Knox, CT Rios, B Natt… - Geroscience, 2020 - Springer
Abstract SARS-CoV-2 virus, the causative agent of the coronavirus infectious disease-19
(COVID-19), is taking the globe by storm, approaching 500,000 confirmed cases and over …

Immune response to COVID-19 in older adults

M Jergović, CP Coplen, JL Uhrlaub… - The Journal of Heart and …, 2021 - Elsevier
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the third highly
pathogenic coronavirus to emerge in the human population in last two decades. SARS-CoV …

[HTML][HTML] Are older people really more susceptible to SARS-CoV-2?

S Zhang, Z Yang, ZN Li, ZL Chen, SJ Yue… - Aging and …, 2022 - ncbi.nlm.nih.gov
Since the outbreak, COVID-19 has spread rapidly across the globe due to its high infectivity
and lethality. Age appears to be one of the key factors influencing the status and progression …