During embryonic brain development, neurogenesis requires the orchestration of gene
expression to regulate neural stem cell (NSC) fate specification. Epigenetic regulation with …

Epigenetic regulatory mechanisms, including DNA methylation, histone modification,
chromatin remodeling, and microRNA expression, play critical roles in cell differentiation …

In the embryonic and adult brain, neural stem cells proliferate and give rise to neurons and
glia through highly regulated processes. Epigenetic mechanisms—including DNA and …

Highlights•Chromatin regulators orchestrate the pace and order of gene expression
programs in differentiating neurons.•Disease-associated mutations in chromatin regulators …

The process of neurogenesis, through which the entire nervous system of an organism is
formed, has attracted immense scientific attention for decades. How can a single neural …

Development is a well-defined stage-to-stage process that allows the coordination and
maintenance of the structure and function of cells and their progenitors, in a complete …

Epigenetic regulation plays an important role in controlling gene expression during complex
processes, such as development of the human brain. Mutations in genes encoding …

During embryonic brain development, neural progenitor/stem cells (NPCs) sequentially give
rise to different subtypes of neurons and glia via a highly orchestrated process. To …

Differentiation of neural stem/precursor cells (NS/PCs) into neurons, astrocytes and
oligodendrocytes during mammalian brain development is a carefully controlled and timed …

Epigenetic mechanisms convey information above and beyond the sequence of DNA, so it is
predicted that they are critical in the complex regulation of brain development and explain …