Somatic stem cells contribute to tissue ontogenesis, homeostasis, and regeneration through
sequential processes. Systematic molecular analysis of stem cell behavior is challenging …

Neural stem cells (NSCs) in the adult mammalian brain serve as a reservoir for the
generation of new neurons, oligodendrocytes, and astrocytes. Here, we use single-cell RNA …

Neural stem cells (NSCs) contribute to plasticity and repair of the adult brain. Niches
harboring NSCs regulate stem cell self-renewal and differentiation. We used comprehensive …

Single-cell RNA sequencing (RNA-Seq) provides rich information about cell types and
states. However, it is difficult to capture rare dynamic processes, such as adult …

Transcriptomes of individual neurons provide rich information about cell types and dynamic
states. However, it is difficult to capture rare dynamic processes, such as adult …

Heterogeneous pools of adult neural stem cells (NSCs) contribute to brain maintenance and
regeneration after injury. The balance of NSC activation and quiescence, as well as the …

Single-cell RNA sequencing offers snapshots of whole transcriptomes but obscures the
temporal RNA dynamics. Here we present single-cell metabolically labeled new RNA …

Epigenomic regulation and lineage-specific gene expression act in concert to drive cellular
differentiation, but the temporal interplay between these processes is largely unknown …

Neurogenesis processes differ in different areas of the cortex in many species, including
humans. Here, we performed single-cell transcriptome profiling of the four cortical lobes and …

Many neurological and psychiatric disorders affect the cerebral cortex, and a clearer
understanding of the molecular processes underlying human corticogenesis will provide …