A genome-wide association study confirms APOE as the major gene influencing survival in long-lived individuals
A Nebel, R Kleindorp, A Caliebe, M Nothnagel… - Mechanisms of ageing …, 2011 - Elsevier
We conducted a case–control genome-wide association study (GWAS) of human longevity,
comparing 664,472 autosomal SNPs in 763 long-lived individuals (LLI; mean age: 99.7 …
comparing 664,472 autosomal SNPs in 763 long-lived individuals (LLI; mean age: 99.7 …
Evidence from case–control and longitudinal studies supports associations of genetic variation in APOE, CETP, and IL6 with human longevity
In this study, we investigated 102 single-nucleotide polymorphisms (SNPs) covering the
common genetic variation in 16 genes recurrently regarded as candidates for human …
common genetic variation in 16 genes recurrently regarded as candidates for human …
ApoE gene and exceptional longevity: insights from three independent cohorts
The ApoE gene is associated with the risk of Alzheimer or cardiovascular disease but its
influence on exceptional longevity (EL) is uncertain. Our primary purpose was to determine …
influence on exceptional longevity (EL) is uncertain. Our primary purpose was to determine …
Genome‐wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited
By studying the loci that contribute to human longevity, we aim to identify mechanisms that
contribute to healthy aging. To identify such loci, we performed a genome‐wide association …
contribute to healthy aging. To identify such loci, we performed a genome‐wide association …
The search for longevity and healthy aging genes: insights from epidemiological studies and samples of long-lived individuals
JM Murabito, R Yuan, KL Lunetta - Journals of Gerontology …, 2012 - academic.oup.com
Genetic factors clearly contribute to exceptional longevity and healthy aging in humans, yet
the identification of the underlying genes remains a challenge. Longevity is a complex …
the identification of the underlying genes remains a challenge. Longevity is a complex …
The Genetic Variability of APOE in Different Human Populations and Its Implications for Longevity
Human longevity is a complex phenotype resulting from the combinations of context-
dependent gene-environment interactions that require analysis as a dynamic process in a …
dependent gene-environment interactions that require analysis as a dynamic process in a …
Genome‐wide linkage analysis for human longevity: Genetics of Healthy Aging Study
Clear evidence exists for heritability of human longevity, and much interest is focused on
identifying genes associated with longer lives. To identify such longevity alleles, we …
identifying genes associated with longer lives. To identify such longevity alleles, we …
APOE Alleles and Extreme Human Longevity
P Sebastiani, A Gurinovich, M Nygaard… - The Journals of …, 2019 - academic.oup.com
We assembled a collection of 28,297 participants from seven studies of longevity and
healthy aging comprising New England Centenarian, Long Life Family, Longevity Gene …
healthy aging comprising New England Centenarian, Long Life Family, Longevity Gene …
Increased effect of the ApoE gene on survival at advanced age in healthy and long‐lived Danes: two nationwide cohort studies
R Jacobsen, T Martinussen, L Christiansen… - Aging cell, 2010 - Wiley Online Library
Studies of Nordic twins suggest an increased genetic influence on mortality with age.
Contrary to this, the heterogeneity hypothesis predicts that the mortality of individuals …
Contrary to this, the heterogeneity hypothesis predicts that the mortality of individuals …
The quest for genetic determinants of human longevity: challenges and insights
Twin studies show that genetic differences account for about a quarter of the variance in
adult human lifespan. Common polymorphisms that have a modest effect on lifespan have …
adult human lifespan. Common polymorphisms that have a modest effect on lifespan have …