Our ability to study early human post-implantation development remains highly limited due
to the ethical and technical challenges associated with intrauterine development of the …

In vitro cultured stem cells with distinct developmental capacities can contribute to
embryonic or extraembryonic tissues after microinjection into pre-implantation mammalian …

Proper development of the human embryo following its implantation into the uterine wall is
critical for the successful continuation of pregnancy. However, the complex cellular and …

In vitro stem cell models that replicate human gastrulation have been generated, but they
lack the essential extraembryonic cells needed for embryonic development, morphogenesis …

Embryo loss and pregnancy disorders are prevalent worldwide, with both conditions
critically associated with dysfunctioning gastrulation processes. Gastrulation and post …

Human pluripotent stem cells provide an inexhaustible model to study human
embryogenesis in vitro. Recent studies have provided diverse models to generate human …

A hallmark of primate postimplantation embryogenesis is the specification of extraembryonic
mesoderm (EXM) before gastrulation, in contrast to rodents where this tissue is formed only …

Mammalian blastocysts comprise three distinct cell lineages essential for development
beyond implantation: the pluripotent epiblast, which generates the future embryo, and …

The complex process by which a single-celled zygote develops into a viable embryo is
nothing short of a miraculous wonder of the natural world. Elucidating how this process is …

Understanding human development is of fundamental biological and clinical importance.
Despite its significance, mechanisms behind human embryogenesis remain largely …