Neuronal activation induces rapid transcription of immediate early genes (IEGs) and longer-
term chromatin remodeling around secondary response genes (SRGs). Here, we use high …

The mammalian cerebral cortex has an unparalleled diversity of cell types, which are
generated during development through a series of temporally orchestrated events that are …

Gene networks have yielded numerous neurobiological insights, yet an integrated view
across brain regions is lacking. We leverage RNA sequencing in 864 samples representing …

INTRODUCTION The cerebral cortex is responsible for higher-order functions in the nervous
system and has undergone substantial expansion in size in primates. The development of …

During mammalian development, differences in chromatin state coincide with cellular
differentiation and reflect changes in the gene regulatory landscape. In the developing brain …

Genetic perturbations of cortical development can lead to neurodevelopmental disease,
including autism spectrum disorder (ASD). To identify genomic regions crucial to …

Neuronal activity-induced gene expression modulates the function and plasticity of the
nervous system. It is unknown whether and to what extent neuronal activity may trigger …

Activity-driven transcription plays an important role in many brain processes, including those
underlying memory and epilepsy. Here we combine genetic tagging of nuclei and ribosomes …

In multicellular organisms, transcription regulation is one of the central mechanisms
modelling lineage differentiation and cell-fate determination. Transcription requires dynamic …

Chromosome conformation capture technologies have revealed important insights into
genome folding. Yet, how spatial genome architecture is related to gene expression and cell …