Cellular senescence as a potential mediator of COVID‐19 severity in the elderly
J Nehme, M Borghesan, S Mackedenski, TG Bird… - Aging cell, 2020 - Wiley Online Library
SARS‐CoV‐2 is a novel betacoronavirus which infects the lower respiratory tract and can
cause coronavirus disease 2019 (COVID‐19), a complex respiratory distress syndrome …
cause coronavirus disease 2019 (COVID‐19), a complex respiratory distress syndrome …
[HTML][HTML] COVID-19 and cellular senescence
CA Schmitt, T Tchkonia, LJ Niedernhofer… - Nature Reviews …, 2023 - nature.com
The clinical severity of coronavirus disease 2019 (COVID-19) is largely determined by host
factors. Recent advances point to cellular senescence, an ageing-related switch in cellular …
factors. Recent advances point to cellular senescence, an ageing-related switch in cellular …
Cellular senescence: friend or foe to respiratory viral infections?
WJ Kelley, RL Zemans… - European Respiratory …, 2020 - Eur Respiratory Soc
Cellular senescence permanently arrests the replication of various cell types and contributes
to age-associated diseases. In particular, cellular senescence may enhance chronic lung …
to age-associated diseases. In particular, cellular senescence may enhance chronic lung …
[HTML][HTML] Role of senescence and aging in SARS-CoV-2 infection and COVID-19 disease
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), has resulted in a global pandemic associated with substantial …
coronavirus 2 (SARS-CoV-2), has resulted in a global pandemic associated with substantial …
[HTML][HTML] Severe COVID-19 and aging: are monocytes the key?
BD Pence - Geroscience, 2020 - Springer
The ongoing pandemic severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)
causes a disproportionate number of severe cases and deaths in older adults. Severe SARS …
causes a disproportionate number of severe cases and deaths in older adults. Severe SARS …
[HTML][HTML] SARS-CoV-2 infection triggers paracrine senescence and leads to a sustained senescence-associated inflammatory response
S Tsuji, S Minami, R Hashimoto, Y Konishi, T Suzuki… - Nature aging, 2022 - nature.com
Reports of post-acute COVID-19 syndrome, in which the inflammatory response persists
even after SARS-CoV-2 has disappeared, are increasing, but the underlying mechanisms of …
even after SARS-CoV-2 has disappeared, are increasing, but the underlying mechanisms of …
COVID‐19 is an emergent disease of aging
COVID‐19 is an ongoing pandemic caused by the SARS‐CoV‐2 coronavirus that poses one
of the greatest challenges to public health in recent years. SARS‐CoV‐2 is known to …
of the greatest challenges to public health in recent years. SARS‐CoV‐2 is known to …
[HTML][HTML] Exploring the relevance of senotherapeutics for the current SARS-CoV-2 emergency and similar future global health threats
The higher death rate caused by COVID-19 in older people, especially those with
comorbidities, is a challenge for biomedical aging research. Here we explore the idea that …
comorbidities, is a challenge for biomedical aging research. Here we explore the idea that …
Aging in COVID-19: Vulnerability, immunity and intervention
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic was first
reported in Wuhan, China in December 2019, moved across the globe at an unprecedented …
reported in Wuhan, China in December 2019, moved across the globe at an unprecedented …
[HTML][HTML] SARS-CoV-2, COVID-19 and the aging immune system
JM Bartleson, D Radenkovic, AJ Covarrubias… - Nature aging, 2021 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic is a global health threat with
particular risk for severe disease and death in older adults and in adults with age-related …
particular risk for severe disease and death in older adults and in adults with age-related …