The COVID-19 pandemic: does our early life environment, life trajectory and socioeconomic status determine disease susceptibility and severity?
C Holuka, MP Merz, SB Fernandes… - International journal of …, 2020 - mdpi.com
A poor socioeconomic environment and social adversity are fundamental determinants of
human life span, well-being and health. Previous influenza pandemics showed that …
human life span, well-being and health. Previous influenza pandemics showed that …
[HTML][HTML] COVID-19, virology and geroscience: a perspective
C Vellas, P Delobel, PDS Barreto, J Izopet - The journal of nutrition, health …, 2020 - Elsevier
A new coronavirus, called SARS-CoV-2, was identified in Wuhan, China, in December 2019.
The SARS-CoV-2 spread very rapidly, causing a global pandemic, Coronavirus Disease …
The SARS-CoV-2 spread very rapidly, causing a global pandemic, Coronavirus Disease …
[HTML][HTML] SARS-CoV-2, immunosenescence and inflammaging: partners in the COVID-19 crime
R Domingues, A Lippi, C Setz, TF Outeiro… - Aging (Albany …, 2020 - ncbi.nlm.nih.gov
Pneumonia outbreak in the city of Wuhan, China, prompted the finding of a novel strain of
severe acute respiratory syndrome virus (SARS-CoV-2). Here, we discuss potential long …
severe acute respiratory syndrome virus (SARS-CoV-2). Here, we discuss potential long …
The possible pathophysiology mechanism of cytokine storm in elderly adults with COVID-19 infection: the contribution of “inflame-aging”
Abstract Purpose Novel Coronavirus disease 2019 (COVID-19), is an acute respiratory
distress syndrome (ARDS), which is emerged in Wuhan, and recently become worldwide …
distress syndrome (ARDS), which is emerged in Wuhan, and recently become worldwide …
SARS-CoV-2 spike protein induces paracrine senescence and leukocyte adhesion in endothelial cells
Increased mortality in COVID-19 cases is often associated with microvascular complications.
We have recently shown that severe acute respiratory syndrome coronavirus 2 (SARS-CoV …
We have recently shown that severe acute respiratory syndrome coronavirus 2 (SARS-CoV …
Immunosenescence exacerbates the COVID-19
Aging and senescence are complex processes associated with increased frailty (Calimport,
Bentley, & Stewart, 2019). Overall, many pathogens are more aggressive and prevalent in …
Bentley, & Stewart, 2019). Overall, many pathogens are more aggressive and prevalent in …
Marked T cell activation, senescence, exhaustion and skewing towards TH17 in patients with COVID-19 pneumonia
S De Biasi, M Meschiari, L Gibellini, C Bellinazzi… - Nature …, 2020 - nature.com
The immune system of patients infected by SARS-CoV-2 is severely impaired. Detailed
investigation of T cells and cytokine production in patients affected by COVID-19 pneumonia …
investigation of T cells and cytokine production in patients affected by COVID-19 pneumonia …
Accelerated biological aging in COVID-19 patients
Chronological age is a risk factor for SARS-CoV-2 infection and severe COVID-19. Previous
findings indicate that epigenetic age could be altered in viral infection. However, the …
findings indicate that epigenetic age could be altered in viral infection. However, the …
Age-dependent regulation of SARS-CoV-2 cell entry genes and cell death programs correlates with COVID-19 severity
Novel coronavirus disease 2019 (COVID-19) severity is highly variable, with pediatric
patients typically experiencing less severe infection than adults and especially the elderly …
patients typically experiencing less severe infection than adults and especially the elderly …
Immunesenescence: a predisposing risk factor for the development of COVID-19?
J Hazeldine, JM Lord - Frontiers in immunology, 2020 - frontiersin.org
Bearing a strong resemblance to the phenotypic and functional remodeling of the immune
system that occurs during aging (termed immunesenescence), the immune response to …
system that occurs during aging (termed immunesenescence), the immune response to …